SAB2501042
Anti-TIP30/CC3 antibody produced in goat
affinity isolated antibody, buffered aqueous solution
别名:
Anti-HIV-1 Tat interactive protein 2, Anti-HTATIP2, Anti-Tat-interacting protein (30 kDa)
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关于此项目
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
ELISA (i), WB
Citations:
5
biological source
goat
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
species reactivity
human
technique(s)
indirect ELISA: suitable, western blot: suitable
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... HTATIP2(10553)
General description
Tat-interacting protein 30 (TIP30), also called CC3/ HIV-1 tat interactive protein 2 (HTATIP2), is a putative tumor suppressor. It is encoded by the gene mapped to human chromosome 11p15.1. TIP30 is primarily localized in cytoplasm and it belongs to short-chain dehydrogenases/reductase (SDR) family. The encoded protein is extensively expressed in various human tissues, such as the heart, brain, lung, kidney and pancreas.
Immunogen
Peptide with sequence AETEALSKLREDFR-C from the N Terminus of the protein sequence according to NP_006401.
Biochem/physiol Actions
Tat-interacting protein 30 (TIP30) has an ability to promote apoptosis and suppress metastasis and angiogenesis. It is also implicated in regulation of DNA repair and tumor cell metabolism. Down-regulated expression of the gene is associated with the development of various cancers, including melanoma, breast cancer, neuroblastoma, glioblastoma, colon cancer, lung cancer and hepatocellular carcinoma. Elevated expression of the gene in glioma cells inhibits tumor proliferation, metastasis and migration. Thus, TIP30 can be considered as a potent target for treating glioma patients.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Physical form
Supplied at 0.5 mg/mL in Tris saline with 0.02% sodium azide and 0.5% bovine serum albumin.
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signalword
Warning
hcodes
pcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2
存储类别
10 - Combustible liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
Overexpression of TIP30 inhibits the growth and invasion of glioma cells
Hu Y, et al.
Molecular Medicine Reports, 13(1), 605-612 (2016)
TIP30: a novel tumor-suppressor gene.
Yu X, et al.
Oncology Research, 22(5-6), 339-348 (2015)
TIP30 Deficiency Increases Susceptibility to Tumorigenesis
Ito M, et al.
Cancer Research, 63(24), 8763-8767 (2003)
Tat-Interacting Protein 30 (TIP30) Expression Serves as a New Biomarker for Tumor Prognosis: A Systematic Review and Meta-Analysis
Xu T, et al.
PLoS ONE, 11(12), e0168408-e0168408 (2016)
Xin Tong et al.
The American journal of pathology, 174(5), 1931-1939 (2009-04-08)
The HIV Tat-interacting protein (TIP30), also called CC3 or HTIP2, is encoded by Tip30, a putative tumor-suppressor gene located on human chromosome 11p15.1. In this study, we investigated the role of TIP30 in the progression and metastasis of lung cancer.
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