SAB2501574
Anti-JAK2 (C-terminal) antibody produced in goat
affinity isolated antibody, buffered aqueous solution
别名:
Janus kinase 2 (a protein tyrosine kinase), Tyrosine-protein kinase JAK2
生物来源
goat
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
表单
buffered aqueous solution
种属反应性
human
技术
flow cytometry: suitable
indirect ELISA: suitable
UniProt登记号
运输
dry ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... JAK2(3717)
一般描述
Janus kinase 2 (JAK2) encodes a tyrosine kinase which belongs to the Jak family of protein kinases. The gene encoding this protein is localized on human chromosome 9p24.
免疫原
Peptide with sequence RVDQVRDNMAG, from the C-terminal region of the protein sequence according to AAC23653.1
生化/生理作用
Janus kinase 2 (JAK2) plays an important role in the activities of cytokine receptors. Overexpression of JAK2 results in neuroblastoma. Mutations in the gene have been linked to primary resistance to PD-1 (anti-programmed death protein 1) blockade therapy.
特点和优势
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
外形
Supplied at 0.5 mg/mL in 20mM Tris (pH 7.3) and 150mM NaCl with 0.02% sodium azide and 0.5% bovine serum albumin.
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储存分类代码
12 - Non Combustible Liquids
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
此项目有
Hodgkin's lymphoma cell lines are characterized by frequent aberrations on chromosomes 2p and 9p including REL and JAK2?
Stefan Joos
International Journal of Cancer. Journal International Du Cancer, 103(4) , 489-495 (2003)
Jak2 Is Essential for Signaling through a Variety of Cytokine Receptors
Evan Parganas
Cell, 93(3), 385- 395 (1998)
Cancer-Associated Fibroblasts Share Characteristics and Protumorigenic Activity with Mesenchymal Stromal Cells.
Borriello L
Cancer Research, 77(18), 5142-5157 (2017)
Primary Resistance to PD-1 Blockade Mediated by JAK1/2 Mutations.
Shin DS
Cancer Discovery, 7(2), 188-201 (2017)
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