SAB2501574
Anti-JAK2 (C-terminal) antibody produced in goat
affinity isolated antibody, buffered aqueous solution
别名:
Janus kinase 2 (a protein tyrosine kinase), Tyrosine-protein kinase JAK2
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关于此项目
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
ELISA (i), FACS
Citations:
4
biological source
goat
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
species reactivity
human
technique(s)
flow cytometry: suitable, indirect ELISA: suitable
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... JAK2(3717)
General description
Janus kinase 2 (JAK2) encodes a tyrosine kinase which belongs to the Jak family of protein kinases. The gene encoding this protein is localized on human chromosome 9p24.
Immunogen
Peptide with sequence RVDQVRDNMAG, from the C-terminal region of the protein sequence according to AAC23653.1
Biochem/physiol Actions
Janus kinase 2 (JAK2) plays an important role in the activities of cytokine receptors. Overexpression of JAK2 results in neuroblastoma. Mutations in the gene have been linked to primary resistance to PD-1 (anti-programmed death protein 1) blockade therapy.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Physical form
Supplied at 0.5 mg/mL in 20mM Tris (pH 7.3) and 150mM NaCl with 0.02% sodium azide and 0.5% bovine serum albumin.
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存储类别
12 - Non Combustible Liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Jak2 Is Essential for Signaling through a Variety of Cytokine Receptors
Evan Parganas
Cell, 93(3), 385- 395 (1998)
Hodgkin's lymphoma cell lines are characterized by frequent aberrations on chromosomes 2p and 9p including REL and JAK2?
Stefan Joos
International Journal of Cancer. Journal International Du Cancer, 103(4) , 489-495 (2003)
Cancer-Associated Fibroblasts Share Characteristics and Protumorigenic Activity with Mesenchymal Stromal Cells.
Borriello L
Cancer Research, 77(18), 5142-5157 (2017)
Primary Resistance to PD-1 Blockade Mediated by JAK1/2 Mutations.
Shin DS
Cancer Discovery, 7(2), 188-201 (2017)
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