Anti-p53 antibody produced in rabbit

Recombinant protein encompassing a sequence within the center region of zebrafish p53.

Suggested starting dilutions are as follows: WB: 1:500-1:3000, IHC-Wm: 1:100-1:500. Not yet tested in other applications. Optimal working dilutions should be determined experimentally by the end user.

Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of bax and fas antigen expression, or by repression of Bcl-2 expression.

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1XPBS, 20% Glycerol (pH7). 0.025% ProClin 300 was added as a preservative.

Purification: Purified by antigen-affinity chromatography

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