SAB2900091
Anti-SLC7A11 antibody produced in rabbit
affinity isolated antibody, buffered aqueous solution
别名:
CCBR1, amino acid transport system xc-, calcium channel blocker resistance protein 1, cystine/glutamate transporter, solute carrier family 7 member 11
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
species reactivity
human
technique(s)
immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
Gene Information
human ... SLC7A11(23657)
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General description
Solute carrier family 7, membrane 11 (SLC7A11), a constituent of the cysteine-glutamate transporter, is located on human chromosome 4q28.31. It belongs to the system xc- light chain family. SLC7A11 gene codes for the cystine-glutamate antiporter Xct.
Immunogen
Synthetic 19 amino acid peptide from N-terminus of human SLC7A11. Percent identity with other species by BLAST analysis: Human, Gorilla, Orangutan, Gibbon (100%); Monkey, Marmoset (95%); Horse (89%); Rat, Dog, Hamster (84%).
Application
Anti-SLC7A11 antibody has been used in western blot analysis.
Biochem/physiol Actions
Solute carrier family 7, membrane 11 (SLC7A11) or xCT participates in glutathione homeostasis, that helps to guard the cells against oxidative stress. It is involved in the pathogenesis of malignant tumors. SLC7A11 is associated with triple negative breast cancer and glioblastoma (GBM).
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Physical form
Solution in phosphate-buffered saline containing less than 0.1% sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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存储类别
12 - Non Combustible Liquids
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
MiR?375/SLC7A11 axis regulates oral squamous cell carcinoma proliferation and invasion.
Wu Y, et al.
Cancer Medicine, 6(7), 1686-1697 (2017)
mTORC2 regulates amino acid metabolism in cancer by phosphorylation of the cystine-glutamate antiporter xCT
Yuchao G, et al.
Molecular Cell, 67(1), 128?138-128?138 (2017)
Decreased expression of the long non-coding RNA SLC7A11-AS1 predicts poor prognosis and promotes tumor growth in gastric cancer.
Yajun L, et al.
Oncotarget, 8(68), 112530?112549-112530?112549 (2017)
SLC7A11, a component of cysteine/glutamate transporter, is a novel biomarker for the diagnosis and prognosis in laryngeal squamous cell carcinoma.
Ma Z, et al.
Oncology Reports, 38(5), 3019-3029 (2017)
Yadong Wu et al.
Cancer medicine, 6(7), 1686-1697 (2017-06-20)
We aimed to detect the functions of miR-375/SLC7A11 axis on oral squamous cell carcinoma (OSCC) cell proliferation and invasion. Expression levels of miR-375 and SLC7A11 in OSCC tissues and cells were measured with RT-qPCR and western blot. Targeting site was
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