Anti-P2RY14 / P2Y14 antibody produced in rabbit

Caspases mediate essential key proteolytic events in inflammatory cascades and the apoptotic cell death pathway. Caspase 12 is involved in the apoptosis triggered by a stress on the endoplasmic reticulum. Caspase-12 is co-localized to the ER with several proteins that are involved in Alzheimer′s disease including gamma-secretase presenilin and beta-amyloid precursor protein (APP). Caspase-12 mediates cytotoxicity induced by amyloid-beta. Caspase 12 activation results in cell death in the absence of the cytochrome c-dependent pathway. Recently caspase-12 has been suggested to affect signaling pathways linking some G-protein coupled receptors to alphaIIbbeta3 activation. Caspase-12 is ubiquitously expressed in mouse tissues.

Synthetic 20 amino acid peptide from C-terminus of human P2RY14 / P2Y14. Percent identity with other species by BLAST analysis: Human (100%); Monkey (95%).

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Solution in phosphate-buffered saline containing less than 0.1% sodium azide.

Supplied at 1 mg/ml

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