SAB3500479
Monoclonal Anti-IL-33 antibody produced in mouse
clone 12H6D12, purified immunoglobulin, buffered aqueous solution
别名:
Anti-Interleukin-33, Anti-NFHEV, Anti-Nuclear factor from high endothelial venules
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关于此项目
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
12H6D12, monoclonal
Application:
ELISA (i), IHC, WB
Citations:
8
biological source
mouse
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
12H6D12, monoclonal
form
buffered aqueous solution
species reactivity
human, mouse
technique(s)
immunohistochemistry: suitable, indirect ELISA: suitable, western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... IL33(90865)
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General description
Interleukin 33 (IL-33) is a potent immunomodulatory cytokine that belongs to the IL-1 family. It is highly expressed in endothelial venules, endothelial cells and epithelium. The gene encoding this protein is localized on human chromosome 9p24.1.
Immunogen
Mouse monoclonal IL-33 antibody was raised against the recombinant IL-33 protein.
Biochem/physiol Actions
Interleukin 33 (IL-33) functions as an extracellular cytokine and also translocates to the nucleus where it inhibits gene expression. IL-33 enhances the secretion of inflammatory cytokines and is associated with T-helper 2-type immune responses. It has been linked to chronic inflammatory diseases. High levels of IL-33 have been observed in the serum of patients with hepatocellular carcinoma and gastric cancer. Polymorphisms in this gene as well as its receptor are linked with atopic dermatitis, allergies and asthma.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Physical form
Supplied in PBS with 0.02% sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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存储类别
12 - Non Combustible Liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Rhinoviral stimuli, epithelial factors and ATP signalling contribute to bronchial smooth muscle production of IL-33.
Calven J
Journal of Translational Medicine (2015)
Esophageal Epithelial-Derived IL-33 Is Upregulated in Patients with Heartburn.
Sei H
PLoS ONE (2016)
Targeting the IL-1 family members in skin inflammation.
Jensen LE
Current Opinion in Investigational Drugs (2010)
Interleukin-33 promotes inflammatory cytokine production in chronic airway inflammation.
Shang J
Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire (2015)
Tumor-infiltrating, interleukin-33-producing effector-memory CD8(+) T cells in resected hepatocellular carcinoma prolong patient survival.
Brunner SM
Hepatology (2015)
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