SAB3500658
Anti-TMEM106A antibody produced in rabbit
affinity isolated antibody
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关于此项目
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Species reactivity:
mouse, human
Application:
ELISA, WB
Citations:
4
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
mol wt
29 kDa
species reactivity
mouse, human
concentration
1 mg/mL
technique(s)
ELISA: suitable, western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... TMEM106A(113277)
General description
Transmembrane protein 106A (TMEM106A) is a type II transmembrane protein localized in mitochondria and plasma membrane. In human chromosome, the gene TMEM106A is localized at 17q21.31.
Immunogen
Antibody was raised against a 14 amino acid peptide near the amino terminus of human TMEM106A.
Biochem/physiol Actions
In gastric cancer cells, transmembrane protein 106A (TMEM106A) is methylated and downregulated. Expression of TMEM106A leads to suppression of cell growth and leads to apoptosis of gastric cancer cells. Expression of TMEM106A in renal cancer suppresses cell growth, cell migration and induces caspase 3 dependent apoptosis. TMEM106A is expressed in all neural cell lines. The mRNA levels of TMEM106A is upregulated in Alzheimer′s disease (AD) brain when compared to non-AD brain.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Physical form
Supplied at 1 mg/mL in PBS with 0.02% sodium azide.
Other Notes
The action of this antibody can be blocked using blocking peptide SBP3500658.
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存储类别
12 - Non Combustible Liquids
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
TMEM106a is a Novel Tumor Suppressor in Human Renal Cancer
Wu C, et al.
Kidney & Blood Pressure Research, 42(5), 853-864 (2017)
TMEM106B expression is reduced in Alzheimer?s disease brains
Satoh J, et al.
Alzheimer's Research & Therapy, 6(2), 17-17 (2014)
Transmembrane protein 106A is silenced by promoter region hypermethylation and suppresses gastric cancer growth by inducing apoptosis
Xu D, et al.
Journal of Cellular and Molecular Medicine, 18(8), 1655-1666 (2014)
Juncai Liu et al.
Journal of cellular biochemistry (2018-11-21)
Transmembrane protein 106A (TMEM106A) has been found to function as tumor suppressor in gastric and renal cancer. However, the role of TMEM106A in nonsmall-cell lung carcinoma (NSCLC) has not been investigated. In this study, we evaluated the expression profile of
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