SAB4100060
Monoclonal Anti-RND1 antibody produced in mouse
clone RND1-A76, culture supernatant
别名:
Anti-ARHS, Anti-GTP-binding protein RHO6, Anti-RHO6, Anti-RHOS, Anti-Ras homolog gene family, member S, Anti-Rho family GTPase 1
biological source
mouse
conjugate
unconjugated
antibody form
culture supernatant
antibody product type
primary antibodies
clone
RND1-A76, monoclonal
form
aqueous solution
mol wt
antigen predicted mol wt 25.9 kDa
species reactivity
human
technique(s)
western blot: suitable
isotype
IgG1
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... RND1(27289)
General description
RND1, a Rho GTPase, belongs to the family Rnd. The gene is located on human chromosome 12q13.12.
Immunogen
RND1 purified recombinant protein
Biochem/physiol Actions
Rho family GTPase 1 (RND1) regulates actin cytoskeleton in several cell types. It is implicated in the Sema3E/plexin-D1-induced inhibition of axon outgrowth in cortical neurons. RND1 plays an important role in plexin signaling. It modulates the dynamics of cell growth and survival. Dysregulation of RND1 is associated with tumorigenesis.
Physical form
Solution in Dulbecco′s Modified Eagle′s Medium with 10% fetal calf serum and 15 mM sodium azide.
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存储类别
12 - Non Combustible Liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
含少量动物源组分生物产品
常规特殊物品
此项目有
RND1 is up-regulated in esophageal squamous cell carcinoma and promotes the growth and migration of cancer cells
Xiang G, et al.
Tumour Biology : the Journal of the International Society For Oncodevelopmental Biology and Medicine, 37(1), 773-779 (2016)
Rnd1 and Rnd3 targeting to lipid raft is required for p190 RhoGAP activation
Oinuma I, et al.
Molecular Biology of the Cell, 23(8), 1593-1604 (2012)
Structural basis of Rnd1 binding to plexin Rho GTPase binding domains (RBDs)
Wang H, et al.
The Journal of Biological Chemistry, 286(29), 26093-26106 (2011)
David Rizzo et al.
American journal of hematology, 88(9), 747-753 (2013-06-05)
It has recently been suggested that the percentage of smudge cells on blood smears from patients with chronic lymphocytic leukemia (CLL) could predict overall survival. However, smudge cells are a cytological artifact influenced by multiple physical factors not related to
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