SAB4200022
Anti-VPS4A antibody produced in rabbit
~1.0 mg/mL, affinity isolated antibody, buffered aqueous solution
别名:
Anti-SKD1, Anti-SKD1-homolog, Anti-SKD1A, Anti-SKD2, Anti-VPS4, Anti-VPS4-1, Anti-Vacuolar protein sorting 4 homolog A
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关于此项目
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
IP, WB
Citations:
8
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen ~50 kDa
species reactivity
rat, human
concentration
~1.0 mg/mL
technique(s)
immunoprecipitation (IP): 10-20 μg using lysates of rat NRK cells, western blot: 1-2 μg/mL using whole extracts of HEK-293T cells over expressing human VPS4A
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... VPS4A(27183)
mouse ... Vps4a(116733)
rat ... Vps4a(246772)
General description
Vacuolar-protein-sorting factor 4A (VPS4A) is an AAAtype ATPase, encoded by the gene mapped to human chromosome 16q22.1. The encoded protein is a member of vacuolar sorting protein family. The protein is characterized by a canonical AAA ATPase cassette followed by an N-terminal MIT (microtubule interacting and trafficking) domain.
Application
Anti-VPS4A antibody produced in rabbit has been used for co-immunoprecipitation and Western blotting.
Biochem/physiol Actions
Vacuolar-protein-sorting factor 4A (VPS4A) plays a vital role in lysosomal/endosomal membrane trafficking. It is also involved in the regulation of exosome biogenesis. Downregulated expression of the gene leads to the development of hepatocellular carcinoma (HCC). Thus, VPS4 is considered to be an effective tumor suppressor for HCC. Mutation of the gene leads to defective multivesicular body formation.
Physical form
Solution in 0.01 M phosphate buffered saline pH 7.4, containing 15 mM sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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存储类别
10 - Combustible liquids
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
Structure and ESCRT-III protein interactions of the MIT domain of human VPS4A
Anna Scott
Proceedings of the National Academy of Sciences of the USA (2005)
A fourth locus for autosomal dominant hypercholesterolemia maps at 16q22.1
Alice M
European Journal of Human Genetics (2010)
Disruption of Neurexin 1 Associated with Autism Spectrum Disorder
Hyung-GooKim
Academic Journal of Interdisciplinary Studies (2008)
Exosomes mediate cell contact?independent ephrin-Eph signaling during axon guidance
Jingyi Gong
The Journal of Cell Biology (2016)
Jingyi Gong et al.
The Journal of cell biology, 214(1), 35-44 (2016-06-30)
The cellular release of membranous vesicles known as extracellular vesicles (EVs) or exosomes represents a novel mode of intercellular communication. Eph receptor tyrosine kinases and their membrane-tethered ephrin ligands have very important roles in such biologically diverse processes as neuronal
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