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安全信息

SAB4200024

Sigma-Aldrich

Anti-Notch 1 antibody, Rat monoclonal

clone ICN 5B5, purified from hybridoma cell culture

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别名:
Anti-Notch homolog 1, translocation-associated (Drosophila), Anti-TAN1, hN1, neurogenic locus notch homolog protein 1, Anti-Translocation-associated notch protein, Monoclonal Anti-Notch 1 antibody produced in rat
NACRES:
NA.41

生物来源

rat

偶联物

unconjugated

抗体形式

purified from hybridoma cell culture

antibody product type

primary antibodies

克隆

ICN 5B5, monoclonal

形式

buffered aqueous solution

分子量

antigen ~120 kDa

species reactivity

human

包装

antibody small pack of 25 μL

浓度

~1.0 mg/mL

technique(s)

western blot: 2-4 μg/mL using whole extract of human Jurkat cells and developing with a sensitive film

同位素/亚型

IgG2b

UniProt登记号

P46531

运输

dry ice

储存温度

−20°C

target post-translational modification

unmodified

Gene Information

human ... NOTCH1(4851)

一般描述

Monoclonal Anti-Notch 1 (rat IgG2b isotype) is derived from the hybridoma ICN 5B5 produced by the fusion of mouse myeloma cells and splenocytes from rat immunized with a recombinant fusion protein corresponding to a fragment of human Notch 1 fusion protein. Notch receptor 1 (Notch1) gene is located on human chromosome 9q34.

应用

Monoclonal Anti-Notch 1 antibody produced in rat has been used in immunoblotting.

生化/生理作用

In chronic obstructive pulmonary disease, notch receptor 1 (Notch1) helps to modulate endothelial apoptosis via the extracellular signal-regulated kinase (ERK) pathway. Overexpression of Notch1 helps to guard endothelial cell from apoptosis. Knockdown of Notch1 results in the enhancement of apoptotic cells. Notch1 serves as a tumor suppressor gene in mammalian epidermis and is a determinant of keratinocyte differentiation. Notch signaling is believed to participate in several human neoplasms including T-cell acute lymphoblastic leukemia.

外形

0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存分类代码

10 - Combustible liquids

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

常规特殊物品

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Notch1 regulates endothelial apoptosis via the ERK pathway in chronic obstructive pulmonary disease
Zong D, et al.
American Journal of Physiology. Cell Physiology, 315(3), C330-C340 (2018)
Regulation of Notch1 gene expression by p53 in epithelial cells
Yugawa T, et al.
Molecular and Cellular Biology, 27(10), 3732-3742 (2007)
Deep sequencing and SNP array analyses of pediatric T-cell acute lymphoblastic leukemia reveal NOTCH1 mutations in minor subclones and a high incidence of uniparental isodisomies affecting CDKN2A
Karrman K, et al.
Journal of Hematology & Oncology, 8(1), 42-42 (2015)
Clinical and molecular characteristics of XPO1 mutations in patients with chronic lymphocytic leukemia
Jain P, et al.
American Journal of Hematology, 91(11), E478-E478 (2016)

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