SAB4200030
Anti-HOXD9 (Internal Region) antibody produced in rabbit
~1.0 mg/mL, affinity isolated antibody, buffered aqueous solution
别名:
Anti-HOX4C, Anti-Homeobox D9, Anti-Hox-4.3
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关于此项目
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
IF, IP, WB
Citations:
4
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen ~40 kDa
species reactivity
human
packaging
antibody small pack of 25 μL
concentration
~1.0 mg/mL
technique(s)
immunoprecipitation (IP): 2.5-5 μg using lysates of HEK-293T cells over expressing human HOXD9, indirect immunofluorescence: 2-5 μg/mL using paraformaldehyde fixed HEK-293T cells over expressing human HOXD9, western blot: 1-2 μg/mL using lysates of HEK-293T cells over expressing human HOXD9
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... HOXD9(3235)
mouse ... Hoxd9(15438)
rat ... Hoxd9(688999)
General description
There are 39 homeobox (HOX) genes in vertebrates. They are divided into four clusters (HOXA−HOXD), located on different chromosomes (7p15, 17q21.2, 12q13 and 2q31). Each cluster contains 9−11 member genes encoding relatively small gene products containing a highly conserved 60-amino-acid region (the homeobox), with DNA-binding activity that contributes to their activity as transcription factors. The HOX genes are evolutionarily conserved.
Application
Anti-HOXD9 (Internal Region) antibody produced in rabbit has been used in:
- immunoblotting
- immunoprecipitation
- immunofluorescence
Biochem/physiol Actions
Homeobox (HOX) transcription factors control important development pathways involved embryo morphogenesis. HOX genes mainly participate in the formation of the body plan during embryonic development. Altered homeobox gene function or expression is implicated in the development of cancers such as leukemias or neoplasms of the breast, prostate, kidney, colon, skin, and brain. HOXD9 is involved in patterning of forelimb, axial skeleton and embryonic segmentation. It might promote cell migration, invasion and metastasis in hepatocellular carcinoma. HOXD9 was shown to be involved in the early stages of normal joint development and also in the pathologic process of arthritis.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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存储类别
10 - Combustible liquids
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
HOXD9 promotes epithelial-mesenchymal transition and cancer metastasis by ZEB1 regulation in hepatocellular carcinoma
Lv X, et al.
Journal of Experimental & Clinical Cancer Research, 34(1), 133-133 (2015)
Role of HOX genes in stem cell differentiation and Cancer
Bhatlekar S, et al.
Stem Cells International, 2018(1), 107-113 (2018)
Expression of murine HOXD9 during embryonic joint patterning and in human T lymphotropic virus type I tax transgenic mice with arthropathy resembling rheumatoid arthritis.
Khoa ND, et al.
Arthritis and Rheumatism, 42(4), 686-696 (1999)
Histone acetylation regulates the expression of HoxD9 transcription factor in endothelial progenitor cells
Iordache F, et al.
Romanian Journal of Morphology and Embryology, 56(1), 107-113 (2015)
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