SAB4200034

Anti-BMI1 (C-terminal) antibody produced in rabbit

Name: Anti-BMI1 (C-terminal) antibody produced in rabbit
Brand: SIGMA

~1.0 mg/mL, affinity isolated antibody, buffered aqueous glycerol solution

别名:

Anti-B lymphoma Mo-MLV insertion region 1 homolog, Anti-PCGF4, Anti-Polycomb group RING finger protein 4, Anti-RNF51, Anti-Ring finger protein 51

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关于此项目

NACRES:

NA.41

UNSPSC Code:

12352203

Conjugate:

unconjugated

Clone:

polyclonal

Application:

IF, IP, WB

Citations:

主要文件

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biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous glycerol solution

mol wt

antigen ~37 kDa

species reactivity

human

packaging

antibody small pack of 25 μL

concentration

~1.0 mg/mL

technique(s)

immunoprecipitation (IP): 2.5-5 μg using lysates of HEK-293T cells over expressing human BMI1, indirect immunofluorescence: 1-2 μg/mL using paraformaldehyde fixed HEK-293T cells over expressing human BMI1, western blot: 2-4 μg/mL using lysates of HEK-293T cells over expressing human BMI1

UniProt accession no.

P35226

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... BMI1(648)

General description

Anti-BMI1 (C-terminal) is produced in rabbit using as the immunogen a synthetic peptide corresponding to a sequence at the C-terminal of human BMI1, conjugated to KLH. The human proto-oncogene BMI1 (also known as polycomb complex protein BMI-1, polycomb group RING finger protein 4, and RING finger protein 51) is a member of the mammalian Polycomb group (Pc-G) genes.

Application

Anti-BMI1 (C-terminal) antibody produced in rabbit has been used in:

western blotting
immunoprecipitation
immunofluorescence

Biochem/physiol Actions

BMI1 (Proto-Oncogene, Polycomb Ring Finger) plays an important role as epigenetic gene silencers during development. Elevated expression of BMI1 is associated with many cancers such as mantle cell lymphoma, B-cell non-Hodgkin′s lymphoma, myeloid leukemia, non-small cell lung cancer, colorectal cancer, breast cancer and prostate cancer. BMI1 has been shown to be also required for self-renewal of hematopoietic stem cells and neuronal stem cells. BMI1 knockout in mice results in defects in hematopoiesis, skeletal patterning and neurological functions.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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存储类别

10 - Combustible liquids

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

常规特殊物品

此项目有

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

119K4834

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Bmi-1 dependence distinguishes neural stem cell self-renewal from progenitor proliferation

Molofsky AV, et al.

Nature, 425(6961), 962-962 (2003)

Bmi-1 cooperates with H-Ras to transform human mammary epithelial cells via dysregulation of multiple growth-regulatory pathways

Datta S, et al.

Cancer Research, 67(21), 10286-10295 (2007)

Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells

Park I K, et al.

Nature, 423(6937), 302-302 (2003)

Bmi1, stem cells, and senescence regulation

Park IK, et al.

The Journal of Clinical Investigation, 113(2), 175-179 (2004)

Endothelial cell-secreted EGF induces epithelial to mesenchymal transition and endows head and neck cancer cells with stem-like phenotype.

Zhaocheng Zhang et al.

Cancer research, 74(10), 2869-2881 (2014-04-02)

Emerging evidence suggests that endothelial cell-secreted factors contribute to the pathobiology of squamous cell carcinoma (SCC) by enhancing invasive migration and resistance to anoikis. Here, we report that SCC cells within the perivascular niche have undergone epithelial to mesenchymal transition

Anti-BMI1 (C-terminal) antibody produced in rabbit

~1.0 mg/mL, affinity isolated antibody, buffered aqueous glycerol solution

选择尺寸

关于此项目

主要文件

属性

biological source

conjugate

antibody form

antibody product type

clone

form

mol wt

species reactivity

packaging

concentration

technique(s)

UniProt accession no.

shipped in

storage temp.

target post-translational modification

Gene Information

说明

General description

Application

Biochem/physiol Actions

Physical form

Disclaimer

安全信息

存储类别

flash_point_f

flash_point_c

法规信息

文件

分析证书(COA)

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