SAB4200051
Anti-JUB (C-terminal) antibody produced in rabbit
~1.0 mg/mL, affinity isolated antibody, buffered aqueous solution
别名:
Anti-Ajuba
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关于此项目
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
IF, WB
Citations:
3
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen ~57 kDa
species reactivity
human, mouse
enhanced validation
recombinant expression
Learn more about Antibody Enhanced Validation
concentration
~1.0 mg/mL
technique(s)
indirect immunofluorescence: 10-20 μg/mL using P19 cells, indirect immunofluorescence: 5-10 μg/mL using HeLa cells and 10-20 μg/mL using P19 cells, western blot: 0.3-0.6 μg/mL using HEK-293T cell lysates expressing human JUB
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... JUB(84962)
General description
JUB, also known as Ajuba, is encoded by the gene mapped to human chromosome 14q11.2. JUB is an adaptor/scaffolding protein and is a member of the zyxin family of cytosolic LIM proteins. The protein is characterized with three related tandem LIM domains at the C terminus associated with unique and distinctive N-terminal, or Pre LIM domains.
Application
Anti-JUB (C-terminal) antibody produced in rabbit has been used in immunoblotting and immunofluorescence.
Biochem/physiol Actions
Anti-JUB (C-terminal) specifically recognizes human and mouse JUB.
JUB mediates various cellular events. It plays a role in cadherin-mediated cell-cell adhesion and in cell migration. JUB is recruited to cadherin complexes through interaction with α catenin, and also influences the localization of p130Cas at focal adhesions and Rac1 activity during cell migration. Altered expression of the gene has been observed in human papillomavirus (HPV) virus.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
Preparation Note
Store at –20 °C. For continuous use, the product may be stored at 2–8 °C for up to one month. For extended storage, freeze in working aliquots at –20 °C. Repeated freezing and thawing, or storage in “frost-free” freezers, is not recommended. If slight turbidity occurs upon prolonged storage, clarify by centrifugation before use. Working dilutions should be discarded if not used within 12 hours.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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存储类别
10 - Combustible liquids
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
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相关内容
Instructions
Genomic insights into head and neck cancer
Beck TN and Golemis EA
Cancer, 1(1), 1-1 (2016)
The LIM protein Ajuba influences p130Cas localization and Rac1 activity during cell migration
Pratt SJ, et al.
The Journal of Cell Biology, 168(5), 813-824 (2005)
The LIM protein, Limd1, regulates AP-1 activation through an interaction with Traf6 to influence osteoclast development
Feng Y, et al.
The Journal of Biological Chemistry, 282(1), 39-48 (2007)
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| SAB4200051-25UL | 04061837875304 |
| SAB4200051-200UL | 04061837875298 |