Anti-JUB (N-terminal) antibody produced in rabbit

JUB also is known as Ajuba is a member of the zyxin family of cytosolic Lin11, Isl-1, Mec-3 (LIM)proteins. This protein is expressed in skin, kidney, liver, lung, and genitourinary organs. The JUB gene is associated with the human chromosome at 14q11.2.

Anti-JUB (N-terminal) antibody produced in rabbit may be used in immunoblotting and immunofluorescence.

Anti-JUB (N-terminal) specifically recognizes human and mouse JUB.

JUB protein mediates various cellular events. It plays a role in cadherin-mediated cell-cell adhesion and cell migration. This protein is recruited to cadherin complexes through interaction with α-catenin. JUB protein also influences the localization of Crk-associated substrate (p130Cas) at focal adhesions and Rac family small guanosine triphosphatase (GTPase 1) (Rac1) activity during cell migration. This protein shuttles between the cytoplasm and the nucleus to affect embryonal cell proliferation. JUB protein interacts with and activates Aurora-A and is required for mitotic commitment in human cells.

Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.

Store at –20 °C. For continuous use, the product may be stored at 2–8 °C for up to one month. For extended storage, freeze in working aliquots at –20 °C. Repeated freezing and thawing, or storage in “frost-free” freezers, is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilutions should be discarded if not used within 12 hours.

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