Monoclonal Anti-PAX9 antibody produced in rat

Anti-PAX9, paired box 9, is a member of the paired box (PAX) family of transcription factors. Members of this gene family typically contain a paired box domain, an octapeptide, and a paired-type homeodomain. These genes play critical roles during fetal de

Monoclonal Anti-PAX9 (rat IgG1 isotype) is derived from the hybridoma paired box 9 (PAX9) 7C2 produced by the fusion of mouse myeloma cells (P3X63Ag8.653) and splenocytes from rat immunized with a recombinant fragment corresponding to a fragment of mouse PAX9 coupled to myelin basic protein (MBP). The PAX gene family encodes a group of transcription factors containing a 128-aa paired DNA-binding domain, and in some cases, a paired-type homeodomain. Nine PAX genes (PAX1-PAX9) has been observed in mammals. Pax9 and Pax1 show high similarities. Pax9 is found in all vertebrates including chick, zebrafish, mouse and man.

Monoclonal Anti-PAX9 antibody produced in rat has been used immunoblotting and immunohistochemistry.

Paired box 9 (PAX9) protein is known to play a role in the formation of various organs and skeletal elements. Mutations in either the PAX1 or the PAX9 genes may produce an inherited skeletal disorder such as the Jarcho-Levin syndrome. Interestingly, progressive loss of PAX9 expression was correlated with increasing malignancy of dysplastic and cancerous epithelium of human esophagus and lung cancer.

Solution in 0.01M phosphate buffered saline pH 7.4, containing 15 mM sodium azide.

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.