SAB4200096
Anti-Coronin 1B antibody produced in rabbit
~1.5 mg/mL, affinity isolated antibody
别名:
Anti-CORO1B, Anti-Coronin-2
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关于此项目
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
IF, WB
Citations:
6
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen ~66 kDa
species reactivity
mouse, rat, human
packaging
antibody small pack of 25 μL
concentration
~1.5 mg/mL
technique(s)
indirect immunofluorescence: 5-10 μg/mL using HS68 cells, western blot: 1.5-3.0 μg/mL using PC12 cell extracts and mouse brain extracts (S1 fraction)
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... CORO1B(57175)
General description
Coronin 1B (CORO1B) is encoded by the gene mapped to human chromosome 11q13.2. CORO1B belongs to the mammalian coronin gene family. The encoded protein is ubiquitously expressed and is mainly present on the leading edge of migrating fibroblasts.
Coronin-1B localizes to sub-membrane areas.
Application
Anti-Coronin 1B antibody produced in rabbit has been used in immunoblotting and immunofluorescence.
Biochem/physiol Actions
Coronin 1B (CORO1B) acts as an actin binding protein. It also plays a major role in controlling whole-cell motility and lamellipodial dynamics. CORO1B also influence neurite outgrowth in a neuronal regeneration model. The encoded protein antagonizes a filament branch stabilizer, cortactin and disassembles actin-related protein (Arp) 2/3-containing actin filament branches by promoting Arp2/3 dissociation.
Coronin-1B has been shown to affect cell motility by regulation of actin-depolymerizing factor (ADF)/cofilin proteins at the leading edge. It targets the cofilin-activating phosphatase slingshot-1L to the leading edge, and thus indirectly regulates cofilin activity.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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存储类别
10 - Combustible liquids
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
低风险生物材料
常规特殊物品
此项目有
Phosphorylation of coronin 1B by protein kinase C regulates interaction with Arp2/3 and cell motility.
Cai L
The Journal of Biological Chemistry, 280, 31913-31923 (2005)
Coronin 1B Coordinates Arp2/3 Complex and Cofilin Activities at the Leading Edge
Cai L
Cell, 128, 915-929 (2007)
Coronin 1B Antagonizes Cortactin and Remodels Arp2/3-Containing Actin Branches in Lamellipodia
Cai L
Cell, 134, 828-842 (2008)
F-actin binding is essential for coronin 1B function in vivo
Cai L, et al.
Journal of Cell Science, 120(10), 1779-1790 (2007)
F-actin binding is essential for coronin 1B function in vivo.
Cai L
Journal of Cell Science, 120, 1779-1790 (2007)
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