SAB4200116
Anti-Coronin-1C (C-terminal) antibody produced in rabbit
~1.5 mg/mL, affinity isolated antibody
别名:
Anti-CORO1C, Anti-Coronin-3, Anti-HCRNN4
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关于此项目
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
IF, WB
Citations:
3
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen ~55 kDa
species reactivity
human, mouse
concentration
~1.5 mg/mL
technique(s)
indirect immunofluorescence: 5-10 μg/mL using NIH3T3 cells, western blot: 1.5-3.0 μg/mL using A431 cell extract
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... CORO1C(23603)
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General description
Coronin 1C (CORO1C) is encoded by the gene mapped to human chromosome 12q24.1. The encoded protein belongs to coronin-like family of proteins. CORO1C consists of 474 amino acids and is ubiquitously expressed in human tissues. CORO1C contains conserved five WD repeats in its N-terminal end and a coiled-coil motif in its C-terminal end.The protein is mainly present at the sites of active actin dynamics including lamellipodia and membrane ruffles.
Biochem/physiol Actions
Coronin 1C (CORO1C) plays a vital role in cytokinesis, motility and signal transduction. It is also implicated in regulation of various cellular processes such as cell proliferation, migration, invadopodia formation and invasion in glioblastoma cells. CORO1C acts as a predictive biomarker for hepatocellular carcinoma (HCC) invasive behavior. The encoded protein negatively regulates cell-matrix adhesion and intestinal epithelial cells (IECs) migration via FAK-mediated signaling.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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存储类别
10 - Combustible liquids
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
Coronin-1C is a novel biomarker for hepatocellular carcinoma invasive progression identified by proteomics analysis and clinical validation.
Wu L
Journal of Experimental & Clinical Cancer Research (2010)
Coronin 1C negatively regulates cell-matrix adhesion and motility of intestinal epithelial cells.
Samarin SN
Biochemical and Biophysical Research Communications, 391, 394-400 (2010)
Isolation and chromosomal assignment of a novel human gene, CORO1C, homologous to coronin-like actin-binding proteins.
Iizaka M
Cytogenetics and Cell Genetics, 88, 221-224 (2000)
相关内容
Instructions
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