Anti-Coronin-1C (C-terminal) antibody produced in rabbit

Coronin 1C (CORO1C) is encoded by the gene mapped to human chromosome 12q24.1. The encoded protein belongs to coronin-like family of proteins. CORO1C consists of 474 amino acids and is ubiquitously expressed in human tissues. CORO1C contains conserved five WD repeats in its N-terminal end and a coiled-coil motif in its C-terminal end.The protein is mainly present at the sites of active actin dynamics including lamellipodia and membrane ruffles.

Coronin 1C (CORO1C) plays a vital role in cytokinesis, motility and signal transduction. It is also implicated in regulation of various cellular processes such as cell proliferation, migration, invadopodia formation and invasion in glioblastoma cells. CORO1C acts as a predictive biomarker for hepatocellular carcinoma (HCC) invasive behavior. The encoded protein negatively regulates cell-matrix adhesion and intestinal epithelial cells (IECs) migration via FAK-mediated signaling.

Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.

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