SAB4200121
Anti-Annexin 4 antibody,Mouse monoclonal
clone ANX47, purified from hybridoma cell culture
别名:
Anti-ANX4, Anti-ANXA4, Anti-PIG28, Anti-Placental anticoagulant protein II, Anti-ZAP36, Anti-Zymogen granule membrane-associated protein, 36-KD
生物来源
mouse
偶联物
unconjugated
抗体形式
purified from hybridoma cell culture
抗体产品类型
primary antibodies
克隆
ANX47, monoclonal
表单
buffered aqueous solution
分子量
antigen 34 kDa
种属反应性
mouse, bovine, human, monkey
包装
antibody small pack of 25 μL
浓度
~1.5 mg/mL
技术
immunohistochemistry: suitable
western blot: 2-4 μg/mL using A431 total cell extracts
同位素/亚型
IgG1
UniProt登记号
运输
dry ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... ANXA4(307)
一般描述
Annexin A4 is encoded by the gene mapped to human chromosome 2p13.3. The encoded protein belongs to the Ca2+-regulated and phospholipid-binding annexin superfamily proteins. Annexin A4 is highly expressed in epithelial cells.
Monoclonal Anti-Annexin 4 (mouse IgG1 isotype) is derived from the hybridoma ANX47 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with a recombinant human Annexin 4 protein.
免疫原
recombinant human Annexin 4 protein
应用
The product may be used in several immunochemical techniques including immunoblotting and immunohistochemistry.
生化/生理作用
Elevated expression of annexin A4 leads to development of various cancers such as colorectal cancer (CRC), esophageal squamous cell carcinoma (ESCC), endometrial carcinoma (EC), gastric cancer (GC), chemoresistant lung cancer (LC), malignant mesothelioma (MM), renal cell carcinoma (RCC), ovarian clear cell carcinoma (OCCC), cholangiocarcinoma, hepatocellular carcinoma (HCC), breast cancer (BC) and laryngeal cancer. Thus, annexin A4 can be used in diagnosis, prognosis and treatment of these cancers. In addition, the encoded protein acts as a tumor suppressor for prostate cancer (PCa) and has a contradictory role for pancreatic cancer (PCC).
The major involvement of Annexin 4 is seen in membrane permeability, exocytosis and regulation of ion channels. Its role in membrane fluidity and membrane trafficking may explain in part the involvement of Annexin 4 in modulating drug resistance in cancer cells. Indeed, Annexin 4 was found to confer chemoresistance in ovarian cancer cells in part by enhancing drug efflux.
外形
Solution in 0.01M phosphate buffered saline pH 7.4, containing 15 mM sodium azide.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
10 - Combustible liquids
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
此项目有
Proteome of the early embryo-maternal dialogue in the cattle uterus
Munoz M, et al.
Journal of Proteome Research, 11(2), 751-766 (2011)
Enhanced expression of Annexin A4 in clear cell carcinoma of the ovary and its association with chemoresistance to carboplatin
Kim A, et al.
International Journal of Cancer. Journal International Du Cancer, 125(10), 2316-2322 (2009)
Fhit Delocalizes Annexin A4 from Plasma Membrane to Cytosol and Sensitizes Lung Cancer Cells to Paclitaxel
Gaudio E
PLoS ONE (2013)
Gene Expression and Proteomic Analysis of Pancreatic Cancer: a Recent Update
CHEN R U
Cancer, Genomics, and Proteomics, 1-10 (2006)
Annexin A4 and cancer.
Wei B
Clinica Chimica Acta; International Journal of Clinical Chemistry, 447, 72-78 (2015)
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