Anti-Annexin 4 antibody,Mouse monoclonal

Annexin A4 is encoded by the gene mapped to human chromosome 2p13.3. The encoded protein belongs to the Ca²⁺-regulated and phospholipid-binding annexin superfamily proteins. Annexin A4 is highly expressed in epithelial cells.

Monoclonal Anti-Annexin 4 (mouse IgG1 isotype) is derived from the hybridoma ANX47 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with a recombinant human Annexin 4 protein.

recombinant human Annexin 4 protein

The product may be used in several immunochemical techniques including immunoblotting and immunohistochemistry.

Elevated expression of annexin A4 leads to development of various cancers such as colorectal cancer (CRC), esophageal squamous cell carcinoma (ESCC), endometrial carcinoma (EC), gastric cancer (GC), chemoresistant lung cancer (LC), malignant mesothelioma (MM), renal cell carcinoma (RCC), ovarian clear cell carcinoma (OCCC), cholangiocarcinoma, hepatocellular carcinoma (HCC), breast cancer (BC) and laryngeal cancer. Thus, annexin A4 can be used in diagnosis, prognosis and treatment of these cancers. In addition, the encoded protein acts as a tumor suppressor for prostate cancer (PCa) and has a contradictory role for pancreatic cancer (PCC).

The major involvement of Annexin 4 is seen in membrane permeability, exocytosis and regulation of ion channels. Its role in membrane fluidity and membrane trafficking may explain in part the involvement of Annexin 4 in modulating drug resistance in cancer cells. Indeed, Annexin 4 was found to confer chemoresistance in ovarian cancer cells in part by enhancing drug efflux.

Solution in 0.01M phosphate buffered saline pH 7.4, containing 15 mM sodium azide.

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