SAB4200128
Anti-DYX1C1 (N-terminal) antibody produced in rabbit
~1.5 mg/mL, affinity isolated antibody
别名:
Anti-DYX1, Anti-DYXC1, Anti-Dyslexia susceptibility 1 candidate 1, Anti-EKN1, Anti-RD
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关于此项目
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
WB
Citations:
9
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen ~48 kDa
species reactivity
human
enhanced validation
recombinant expression
Learn more about Antibody Enhanced Validation
concentration
~1.5 mg/mL
technique(s)
western blot: 1-2 μg/mL using lysates of HEK-293T cells overexpressing human DYX1C1
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... DYX1C1(161582)
General description
Anti-DYX1C1 (N-terminal) is produced in rabbit using as the immunogen a synthetic peptide corresponding to a sequence at the N-terminal of human DYX1C1, conjugated to KLH. DYX1C1 is expressed in brain and the protein resides in the nucleus.
DYX1C1/dynein axonemal assembly factor 4 (DNAAF4) gene with 10 exons, extending over a length of ~78 kb on genomic DNA, is mapped to human chromosome 15q21.3. DYX1C1 contains a nuclear tetratricopeptide repeat domain.
Application
Anti-DYX1C1 (N-terminal) antibody produced in rabbit has been used in immunoblotting.
Anti-DYX1C1 (N-terminal) antibody produced in rabbit has been used in immunofluorescence studies.
Biochem/physiol Actions
DYX1C1 has been recently implicated as a cancer biomarker in colorectal cancer.
DYX1C1/dynein axonemal assembly factor 4 (DNAAF4) plays a vital role in neuronal migration and regulation of estrogen receptor signaling. Mutation in the gene increases the risk of susceptibility to developmental dyslexia (DD). Variations in the gene is also associated with the deficits in reading, orthographic skills and spelling.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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存储类别
10 - Combustible liquids
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
Genetic and protein interaction studies between the ciliary dyslexia candidate genes DYX1C1 and DCDC2.
Bieder, et al.
BMC molecular and cell biology, 24, 20-20 (2023)
A family-based association study does not support DYX1C1 on 15q21.3 as a candidate gene in developmental dyslexia
Marino C
European Journal of Human Genetics, 13, 491-499 (2005)
Association of SNPs of DYX1C1 with developmental dyslexia in an Indian population.
Venkatesh SK
Psychiatric Genetics, 24, 10-20 (2014)
Association of the DYX1C1 dyslexia susceptibility gene with orthography in the Chinese population.
Zhang Y
PLoS ONE, 7 (2012)
Molecular networks of DYX1C1 gene show connection to neuronal migration genes and cytoskeletal proteins.
Tammimies K
Biological Psychiatry, 73, 583-590 (2013)
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