Anti-PNK antibody ,Mouse monoclonal

Monoclonal Anti-PNK (mouse IgG1 isotype) is derived from the hybridoma H101.5 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with a human polynucleotide kinase 3′-phosphatase (PNK) recombinant protein. PNK comprises of a central phosphatase domain that is flanked by an N-terminal forkhead-associated (FHA) domain and a C-terminal kinase domain on either sides.

human PNK recombinant protein.

Monoclonal Anti-PNK antibody produced in mouse has been used in immunoblotting and immunoprecipitation.

PNK is a mammalian DNA repair enzyme which catalyzes the phosphorylation of DNA 5′-hydroxyl termini and the dephosphorylation of 3′-phosphate termini. PNK is involved in the single-strand break repair pathway and the non-homologous end joining pathway for double strand break repair. Mutations in PNK result in neurological abnormalities.

Polynucleotide kinase 3′-phosphatase (PNKP or PNK) is a nuclear protein that repairs DNA strand breaks induced by oxidative damage or ionizing radiation. Genetic alterations in PNKP have been linked to seizures, microcephaly and deficiencies in DNA repair mechanisms .

0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。

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