SAB4200135
Anti-FIP200 (C-terminal) antibody produced in rabbit
~1 mg/mL, affinity isolated antibody
别名:
Anti-200 kDa FAK family kinase-interacting protein, Anti-CC1, Anti-DRAGOU14, Anti-RB1-inducible coiled-coil 1, Anti-RB1CC1
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关于此项目
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
WB
Citations:
17
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen ~200 kDa
species reactivity
canine, mouse, bovine, monkey, rat, human
concentration
~1 mg/mL
technique(s)
western blot: 1-2 μg/mL using whole extracts of HEK-293 cells overexpressing human FIP200
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... RB1CC1(9821)
mouse ... Rb1cc1(12421)
rat ... Rb1cc1(312927)
General description
FIP200 (focal adhesion kinase family interacting protein of 200 kDa), also known as RB1CC1 (retinoblastoma 1-inducible coiled-coil 1), is a multifunctional protein. It is mainly localized in the cytoplasm. The FIP200 gene is mapped to human chromosome 8q11.23.
Application
Anti-FIP200 (C-terminal) antibody produced in rabbit has been used in immunoblotting.
Biochem/physiol Actions
Anti-FIP200 (C-terminal) recognizes human FIP200.
Focal adhesion kinase family interacting protein of 200 kDa (FIP200) interacts with UNC-51-like kinase (ULK 1) and is essential for autophagy. It also interacts with Pyk2 (proline-rich tyrosine kinase 2), FAK (focal adhesion kinase), TSC1 (TSC complex subunit 1), p53, apoptosis signal-regulating kinase 1 (ASK1) and TRAF2 (TNF receptor associated factor 2) and regulates cell growth, cell proliferation, cell survival, cell adhesion and cell migration. Deficiency in FIP200 is associated with embryonic death and cancer development.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
Preparation Note
Store at –20 °C. For continuous use, store at 2–8 °C for up to one month. For extended storage, freeze in working aliquots. Repeated freezing and thawing, or storage in “frost-free” freezers, is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilutions should be discarded if not used within 12 hours.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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存储类别
12 - Non Combustible Liquids
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
Christopher P Webster et al.
The EMBO journal, 35(15), 1656-1676 (2016-06-24)
A GGGGCC hexanucleotide repeat expansion in the C9orf72 gene is the most common genetic cause of amyotrophic lateral sclerosis and frontotemporal dementia (C9ALS/FTD). C9orf72 encodes two C9orf72 protein isoforms of unclear function. Reduced levels of C9orf72 expression have been reported
FIP200, a key signaling node to coordinately regulate various cellular processes
Gan B and Guan JL
Cellular Signalling, 20(5), 787-794 (2008)
The role of the Atg1/ULK1 complex in autophagy regulation
Mizushima N
Current Opinion in Cell Biology, 22(2), 132-139 (2010)
Mahipal V Suraneni et al.
Cell cycle (Georgetown, Tex.), 13(11), 1798-1810 (2014-04-16)
15-Lipoxygenase-2 (15-LOX2) is a human-specific lipid-peroxidizing enzyme most prominently expressed in epithelial cells of normal human prostate but downregulated or completely lost in>70% of prostate cancer (PCa) cases. Transgenic expression of 15-LOX2 in the mouse prostate surprisingly causes hyperplasia. Here
Investigation of Androgen Responsive Elements in Some Autophagy Related Genes via In Silico Analysis.
Erzurumlu Y
Suleyman Demirel University The Journal of Health Science, 11(1) (2020)
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