Anti-VILIP-1 (C-terminal) antibody produced in rabbit

Visinin-like protein-1 (VILIP-1) belongs to a large family of neuronal Ca²⁺ sensor (NCS) proteins. The VILIP subfamily includes VILIP-1, VILIP-2, VILIP-3, hippocalcin and neurocalcin-δ. VILIP-1 is primarily expressed in the brain, particularly in the hippocampus. NCS proteins possess four EF-hand Ca²⁺-binding motifs, that facilitate their association with lipid bilayers.

Anti-VILIP-1 (C-terminal) antibody produced in rabbit has been used in immunoblotting and immunoprecipitation.

Visinin-like protein-1 (VILIP-1) associates with the plasma membrane and Golgi membranes and modulates the signaling of cAMP and cGMP in neuronal cells. It upregulates the expression of functional α4β2 neuronal nicotinic acetylcholine receptors in hippocampal neurons. VILIP-1 modulates the activity of guanylyl cyclase B through clathrin dependent receptor cycling, supporting a role for VILIP-1 in membrane trafficking in the central nervous system (CNS). VILIP-1 is implicated in the pathology of CNS disorders including Alzheimer′s disease, schizophrenia and as a biomarker in ischemic stroke. VILIP-1 expression is regulated during induction of hippocampal synaptic plasticity, underlying learning and memory processes. Neuronal Ca²⁺ sensor (NCS) proteins are involved in a variety of Ca²⁺-dependent signal transduction processes in neurons.

Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.

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