Anti-Tensin 2 antibody produced in rabbit

Tensins are a family of focal adhesion proteins that link the extracellular matrix (ECM) and the cytoskeleton via integrins. The tensin family includes four members: tensin 1-4, encoded by different genes. Tensin proteins consists of homologous C1, protein tyrosine phosphatase (PTPase), C2, SH2 and phosphotyrosine-binding domain (PTB) domains. Tensin 2 is very similar to tensin1 at its N- and C-terminus. They have similar actin binding domain, SH2 and PTB domains. Tensin 2 is a binding partner for Axl receptor tyrosine kinase. Tensin 2 mRNA is highly expressed in heart, liver, kidney and skeletal muscle.

Anti-Tensin 2 antibody produced in rabbit has been used in immunoblotting.

Tensins play an important role in regulating cell shape and motility. Abnormal expression of tensins are implicated in various forms of human cancers. Expression of tensin 2 and tensin 3 are markedly reduced in a panel of diverse human cancer cell lines and all four genes are downregulated in human kidney cancer. Tensin 2 induces growth inhibition and apoptosis in hepatocellular carcinoma (HCC) cell lines. Tensin 2 interacts directly with deleted in liver cancer 1 (DLC1), a tumor suppressor protein often deleted and downregulated in HCC cell lines and other types of cancers. Tensin 2 may be important for normal kidney function in vivo.

Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.

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