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Merck
CN

SAB4200169

Sigma-Aldrich

Anti-PPM1M (C-terminal) antibody produced in rabbit

~1.0 mg/mL, affinity isolated antibody

别名:

Anti-PP2C-ETA, Anti-PP2CE, Anti-Protein phosphatase 2C, ETA isoform, Anti-Protein phosphatase, magnesium-dependent, 1M

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UNSPSC代码:
12352203
NACRES:
NA.44
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生物来源

rabbit

偶联物

unconjugated

抗体形式

affinity isolated antibody

抗体产品类型

primary antibodies

克隆

polyclonal

表单

buffered aqueous solution

分子量

~33 kDa

种属反应性

human

包装

antibody small pack of 25 μL

浓度

~1.0 mg/mL

技术

immunoprecipitation (IP): 2.5-5.0 μg using lysates of HEK-293T cells over-expressing human PPM1M

UniProt登记号

运输

dry ice

储存温度

−20°C

靶向翻译后修饰

unmodified

基因信息

human ... PPM1M(132160)

一般描述

Protein phosphatase, Mg2+/Mn2+ dependent 1M (PPM1M), also known as protein phosphatase 2C isoform η (PP2C-η or PP2CE) is a novel member of the protein serine/threonine phosphatase 2C family. At least 14 distinct PP2C family members have been identified in mammalian cells, all sharing six conserved structural motifs. PPM1M is ubiquitously expressed and localizes in the nucleus of cells. The PPM1M gene is mapped to human chromosome 3p21.2.

应用

Anti-PPM1M (C-terminal) antibody is suitable for use in immunoprecipitation (2.5-5.0 μg) using lysates of HEK-293T cells over-expressing human PPM1M. The product may also be used for western blot (approx. 33 kDa).
Anti-PPM1M (C-terminal) antibody produced in rabbit is suitable for immunoblotting and immunoprecipitation.

生化/生理作用

Anti-PPM1M (C-terminal) recognizes human PPM1M.
Decreased PPM1M gene expression is associated with the inhibition of Herpes simplex virus 1 (HSV-1) infection.
Dephosphorylation of inhibitor of nuclear factor κ B kinase subunit β (IKKβ) by protein phosphatase, Mg2+/Mn2+ dependent 1M (PPM1M) inhibits interleukin-1 (IL-1)-nuclear factor κB (NF-κB) mediated signal transduction. Thus, PPM1M may have implications in regulating pro-inflammatory responses.

外形

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide

制备说明

Store at –20 °C. For continuous use, store at 2–8 °C for up to one month. For extended storage, freeze in working aliquots. Repeated freezing and thawing, or storage in “frost-free” freezers, is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilutions should be discarded if not used within 12 hours.

免责声明

Unless otherwise stated in our catalog, our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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储存分类代码

10 - Combustible liquids

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

新产品
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Yue Xu et al.
Medical science monitor : international medical journal of experimental and clinical research, 26, e922710-e922710 (2020-05-26)
BACKGROUND Keratitis is a complex condition in humans and is the second most common cause of legal blindness worldwide. MATERIAL AND METHODS To reveal the genomic loci underlying keratitis, we performed functional annotations of SNP-based and gene-based genome-wide association studies
Shinri Tamura et al.
Cancer science, 97(7), 563-567 (2006-07-11)
Although unlimited proliferation of cancer cells is supported by multiple signaling pathways involved in the regulation of proliferation, survival, and apoptosis, the molecular mechanisms coordinating these different pathways to promote the proliferation and survival of cancer cells have remained unclear.
Takeaki Henmi et al.
The Biochemical journal, 423(1), 71-78 (2009-07-15)
IL-1 (interleukin-1) is a pro-inflammatory cytokine that has a variety of effects during the process of inflammation. Stimulating cells with IL-1 initiates a signalling cascade that includes the activation of NF-kappaB (nuclear factor kappaB), and subsequently induces a variety of
Ken-ichiro Komaki et al.
Biochimica et biophysica acta, 1630(2-3), 130-137 (2003-12-05)
We have cloned a novel member of the mouse protein phosphatase 2C family, PP2Ceta. Sequence analysis suggests that PP2Ceta, PP2Czeta and NERPP-2C constitute a unique subgroup of the PP2C family. PP2Ceta had extremely low activity against alpha-casein compared with PP2Calpha

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