SAB4200177
Anti-SORBS2 antibody, Mouse monoclonal
clone S13N, purified from hybridoma cell culture
别名:
Anti-ARGBP2, Anti-Arg binding protein 2; Arg/Abl-interacting protein 2, Anti-Sorbin and SH3 domain containing 2
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关于此项目
NACRES:
NA.44
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
S13N, monoclonal
Application:
ICC, WB
Citations:
3
biological source
mouse
conjugate
unconjugated
antibody form
purified from hybridoma cell culture
antibody product type
primary antibodies
clone
S13N, monoclonal
form
buffered aqueous solution
mol wt
antigen ~85 kDa
species reactivity
human
packaging
antibody small pack of 25 μL
concentration
~1.0 mg/mL
technique(s)
immunocytochemistry: suitable, western blot: 5-10 μg/mL using HeLa total cell extracts
isotype
IgG1
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... SORBS2(8470)
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General description
SORBS2 or ArgBP2 is an adapter protein that regulates actin-dependent cell adhesion and migration. ArgBP2 facilitates the ubiquitination and degradation of c-Abl. In heart muscle cells, ArgBP2 is localized at Z-disks of sarcomeres and may regulate elasticity of cardiac sarcomeres, whereas in the epithelial cells ArgBP2 may modulate the assembly of signaling complexes in stress fibers . Anti-SORBS2 antibody is specific for human SORBS2 (85 kDa). Staining of the SORBS2 band in immunoblotting is specifically inhibited with the immunizing peptide.
Immunogen
synthetic peptide corresponding to amino acids 29-46 of human SORBS2, conjugated to KLH.
Application
Anti-SORBS2 antibody is suitable for use in western blot (5-10 μg/mL using HeLa total cell extracts) and immunocytochemistry.
Physical form
Solution in 0.01M phosphate buffered saline pH 7.4, containing 15 mM sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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存储类别
10 - Combustible liquids
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Julie Roignot et al.
Cell adhesion & migration, 3(2), 167-170 (2009-03-06)
ArgBP2, a member of the SoHo family of adapter proteins, is a regulator of actin-dependent processes such as cell adhesion and migration. Recent data from our lab revealed that by regulating adhesion and migration of pancreatic cancer cells, ArgBP2 is
B Wang et al.
The Journal of biological chemistry, 272(28), 17542-17550 (1997-07-11)
Arg and c-Abl represent the mammalian members of the Abelson family of protein-tyrosine kinases. A novel Arg/Abl-binding protein, ArgBP2, was isolated using a segment of the Arg COOH-terminal domain as bait in the yeast two-hybrid system. ArgBP2 contains three COOH-terminal
Philippe Soubeyran et al.
The Biochemical journal, 370(Pt 1), 29-34 (2002-12-12)
The mechanisms leading to the ubiquitination and degradation of the activated c-Abl kinase have not yet been identified. We found that the multi-adaptor protein ArgBP2 links c-Abl to the ubiquitin ligase Cbl. Phosphorylation of Cbl and ArgBP2 by c-Abl resulted
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