Anti-CACYBP antibody,Mouse monoclonal

Monoclonal Anti-CACYBP (mouse IgG1 isotype) is derived from the hybridoma CABP7 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with a recombinant fusion protein. The protein is a human ortholog of mouse calcyclin (S100A6)-binding protein and an element of novel ubiquitin ligase complex.

The gene CACYBP (calcyclin binding protein) is mapped to human chromosome 1q25.1. It is widely expressed in human tissues.

Anti-CACYBP antibody, Mouse monoclonal is suitable for immunoblotting.

CACYBP (calcyclin binding protein) is a part of the ubiquitination machinery and is involved in the degradation of β-catenin. It can interact with S100, SIAH1 (seven in absentia homolog 1) and SKP1 (S-phase kinase-associated protein 1). CACYBP is involved in proliferation, differentiation, multidrug resistance and tumorigenicity. It can work as an oncogene and as a tumor suppressor. In glioma cells, CACYBP enhances the cellular proliferation.

Monoclonal Anti-CACYBP recognizes human, dog, bovine, and monkey CACYBP.

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide

Store at −20 °C. For continuous use, store at 2–8 °C for up to one month. For extended storage, freeze at –20 °C in working aliquots. Repeated freezing and thawing, or storage in “frost-free” freezers, is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilution samples should be discarded if not used within 12 hours.

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