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Merck
CN

SAB4200189

Sigma-Aldrich

Anti-Sumo-1 antibody, Rat monoclonal

clone 4D12, purified from hybridoma cell culture

别名:

Anti-DAP1, Anti-GMP1, Anti-OFC10 CLEFT LIP WITH OR WITHOUT CLEFT PALATE, NONSYNDROMIC, 10, Anti-SMT3 suppressor of mif two 3 homolog 1 SENTRIN PIC1 OROFACIAL CLEFT 10, INCLUDED; OFC10, Anti-SMT3H3 SMT3C, Anti-UBL1, SMT3, YEAST, HOMOLOG 3, Anti-small ubiquitin-like modifier 1, Anti-ubiquitin-like 1, Monoclonal Anti-Sumo-1, SUMO-1, SUMO1

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关于此项目

MDL编号:
MFCD02096449
UNSPSC代码:
12352203
NACRES:
NA.41

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偶联物

unconjugated

抗体形式

purified from hybridoma cell culture

抗体产品类型

primary antibodies

克隆

4D12, monoclonal

表单

buffered aqueous solution

分子量

~12 kDa

种属反应性

human, rat, mouse

浓度

~1.0 mg/mL

技术

immunocytochemistry: suitable
western blot: 2-4 μg/mL using HeLa cell extracts

同位素/亚型

IgG2a

UniProt登记号

P63165

运输

dry ice

储存温度

−20°C

靶向翻译后修饰

unmodified

基因信息

human ... SUMO1(7341)
mouse ... Sumo1(22216)
rat ... Sumo1(301442)

一般描述

Monoclonal Anti-Sumo-1 (rat IgG2a isotype) is derived from the hybridoma 4D12 produced by the fusion of mouse myeloma cells (SP2/0) and splenocytes from rat immunized with a fusion protein of human SUMO1.
SUMO1 (small ubiquitin-related modifier), also called as Pic1 (inner centromere protein-related protein), Ubl1 (ubiquitin-like protein), hSmt3 (human homolog 3), or sentrin, is mainly expressed in the nucleus. The gene encoding SUMO1 is mapped to human chromosome 2q33. SUMO1 belongs to ubiquitin-like protein family and it consists of 101 amino acids.

免疫原

fusion protein of human SUMO1

应用

Monoclonal Anti-Sumo-1 has been used in immunocytochemistry.
Monoclonal Anti-Sumo-1 has been used in western blotting.

生化/生理作用

Sumo-1 interacts with dsDNA and competes with other protein-DNA interactions.
Suppressing SUMO1 (small ubiquitin-related modifier) inhibits multiplication and induces apoptosis of gastric cancer SGC-7901 cells. It is essential for HCV (hepatitis C virus) replication. Deletion of SUMO1 blocks the aggregation of lipid droplets. It is also implicated in mitochondrial fission.

外形

Solution in 0.01 M phosphate buffered saline pH 7.4, containing 15 mM sodium azide.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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储存分类代码

10 - Combustible liquids

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

常规特殊物品
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分析证书(COA)

Lot/Batch Number
0000128668
0000108940
070M4776

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SUMO-1 possesses DNA binding activity
Eilebrecht S, et al.
BMC Research Notes, 3(1), 146-146 (2010)
Donatella Ponti et al.
PloS one, 9(5), e96037-e96037 (2014-05-03)
EGR1 is an immediate early gene with a wide range of activities as transcription factor, spanning from regulation of cell growth to differentiation. Numerous studies show that EGR1 either promotes the proliferation of stimulated cells or suppresses the tumorigenic growth
The genetic basis of cleft lip and cleft palate
Veros C
Aristotle University Medical Journal, 43, 25-36 (2016)
SUMO-1 Gene Silencing Inhibits Proliferation and Promotes Apoptosis of Human Gastric Cancer SGC-7901 Cells.
Jin L
Cellular Physiology and Biochemistry, 41, 987-998 (2017)
The Transcription Factor EGR1 Localizes to the Nucleolus and Is Linked to Suppression of Ribosomal Precursor Synthesis
Ponti D
PLoS ONE, 9 (2014)
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