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Merck
CN

SAB4200221

Sigma-Aldrich

Anti-GrpL/GADS antibody, Mouse monoclonal

clone UW40, purified from hybridoma cell culture

别名:

Anti-GRAP2, Anti-GRB2-related adaptor protein 2, Anti-GRB2-related protein with insert domain, Anti-GRB2L, Anti-GRBLG, Anti-GRBX, Anti-GRF40, Anti-GRID, Anti-GRPL, Anti-Growth factor receptor-bound protein 2-related adaptor protein 2, Anti-Hematopoietic cell-associated adapter protein GrpL, Anti-Mona, Anti-P38, GRB-2-like protein, Anti-RP3-370M22.1, Anti-SH3-SH2-SH3 adapter Mona

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关于此项目

MDL编号:
MFCD03455450
UNSPSC代码:
12352203
NACRES:
NA.44

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生物来源

mouse

偶联物

unconjugated

抗体形式

purified from hybridoma cell culture

抗体产品类型

primary antibodies

克隆

UW40, monoclonal

表单

buffered aqueous solution

分子量

antigen ~41 kDa

种属反应性

human, mouse

浓度

~1.0 mg/mL

技术

flow cytometry: suitable
immunoprecipitation (IP): suitable
western blot: 0.5-1.0 μg/mL using whole extracts of human Jurkat cells

同位素/亚型

IgG2a

UniProt登记号

O75791

储存温度

−20°C

靶向翻译后修饰

unmodified

基因信息

human ... GRAP2(9402)

一般描述

GrpL is a SH2- and SH3-domain containing adaptor protein that regulates tyrosine kinase signaling in leukocytes. This adaptor protein associates with SLP-76 and subsequently enhances NF-AT activation in T cells. GrpL also interacts with gab-1 . Monoclonal Anti-GrpL/GADS antibody is specific for human and mouse GrpL.

免疫原

fusion protein expressing human GrpL.

应用

Monoclonal Anti-GrpL/GADS antibody is suitable for use in western blot (0.5-1.0 μg/mL using whole extracts of human Jurkat cells), immunoprecipitation and flow cytometry.

外形

0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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储存分类代码

12 - Non Combustible Liquids

WGK

WGK 1

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

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分析证书(COA)

Lot/Batch Number
0000141289
0000137217
080M4835

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C L Law et al.
The Journal of experimental medicine, 189(8), 1243-1253 (1999-04-20)
Propagation of signals from the T cell antigen receptor (TCR) involves a number of adaptor molecules. SH2 domain-containing protein 76 (SLP-76) interacts with the guanine nucleotide exchange factor Vav to activate the nuclear factor of activated cells (NF-AT), and its
M Qiu et al.
Biochemical and biophysical research communications, 253(2), 443-447 (1999-01-08)
The SH2- and SH3-containing adaptor molecules serve to recruit cytosolic signal-transducing molecules to the activated receptor tyrosine kinases. In this study, we report the molecular cloning of a novel adaptor-like protein, Grap-2 (Grb-2 related adaptor protein 2), using the multisubstrate

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