Anti-CD3ζ chain antibody, Mouse monoclonal

Monoclonal Anti- CD3ζ chain (mouse IgG1 isotype) is derived from the hybridoma TCR-48 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with a synthetic peptide corresponding to a fragment of mouse CD3ζ chain conjugated to KLH. CD3ζ is a 16-kDa transmembrane protein, which consists of a short extracellular domain and a long intracellular domain including immunoreceptor tyrosine-based activation motif (ITAM). It is a subunit of T cell receptor chains (TCR), which is expressed by T cells and natural killer (NK) cells.

Monoclonal Anti-CD3ζ chain antibody produced in mouse has been used in immunoblotting and immunoprecipitation.

CD3ζ is required for T cell receptor chains (TCR) complex assembly and expression. It is involved in immunity, neuronal development and synaptic plasticity. Downregulation of TCR ζ-chain expression and impairment of T-cell function is associated with systemic lupus erythematosus (SLE), rheumatoid arthritis, cancer and infectious diseases. Altered expression and function of CD3ζ in T cells is linked to hematological diseases.

Solution in 0.01M phosphate buffered saline pH 7.4, containing 15 mM sodium azide.

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