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Merck
CN

SAB4200239

Sigma-Aldrich

Anti-Alpha4 antibody, Mouse monoclonal

clone 5F6, purified from hybridoma cell culture

别名:

Anti-IGBP1, Anti-Immunoglobulin-binding protein 1

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MDL编号:
UNSPSC代码:
12352203
NACRES:
NA.44
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生物来源

mouse

偶联物

unconjugated

抗体形式

purified from hybridoma cell culture

抗体产品类型

primary antibodies

克隆

5F6, monoclonal

表单

buffered aqueous solution

分子量

antigen ~40 kDa

种属反应性

human, mouse

浓度

~1 mg/mL

技术

western blot: 1-2 μg/mL using whole extracts of mouse 3T3 or human HeLa cells

同位素/亚型

IgG1

UniProt登记号

运输

dry ice

储存温度

−20°C

靶向翻译后修饰

unmodified

基因信息

human ... IGBP1(3476)
mouse ... Igbp1(18518)

一般描述

α 4 is a phosphoprotein that is expressed in a wide range of tissues, including pancreas, lymph node, thymus, kidney, leukocytes, fetal liver, heart, and brain. This phosporpotein associates with protein phosphatases 2A, 4, and 6 to regulate the rapamycin-sensitive pathway mediated by FRAP. α4 also binds to MID-1 and subsequently modulates PP2A function . Monoclonal Anti-α4 antibody is specific for human and mouse α4 (approx. 40 kDa).

免疫原

mouse Alpha4 fusion protein. The corresponding sequence shares 80% homology with human Alpha4.

应用

Monoclonal Anti-α4 antibody is suitable for use in western blot (1-2 μg/mL using whole extracts of mouse 3T3 or human HeLa cells).

外形

0.01M 磷酸缓冲盐溶液,pH 7.4,含 15mM 叠氮化钠。

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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储存分类代码

12 - Non Combustible Liquids

WGK

WGK 1

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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J Chen et al.
Biochemical and biophysical research communications, 247(3), 827-832 (1998-07-02)
Protein phosphatases participate in the regulation of a variety of cellular processes. Control of their enzymatic activity and specificity is made possible largely by an array of regulatory subunits. Novel serine/threonine phosphatases--PP4 and PP6 in human cells--have been discovered recently
Haijuan Du et al.
PloS one, 6(12), e28877-e28877 (2011-12-24)
Alpha4 is a regulatory subunit of the protein phosphatase family of enzymes and plays an essential role in regulating the catalytic subunit of PP2A (PP2Ac) within the rapamycin-sensitive signaling pathway. Alpha4 also interacts with MID1, a microtubule-associated ubiquitin E3 ligase
Marketa Koncicka et al.
PloS one, 15(4), e0229781-e0229781 (2020-04-29)
Lamin C2 (LMN C2) is a short product of the lamin a gene. It is a germ cell-specific lamin and has been extensively studied in male germ cells. In this study, we focussed on the expression and localization of LMN
M Onda et al.
Genomics, 46(3), 373-378 (1998-01-27)
To study the function of the B cell signal transduction molecule alpha 4 (IGBP1), we isolated a human alpha 4 (IGBP1) gene that has sequence similarity to the yeast protein (TAP42) involved in the rapamycin-sensitive signal transduction pathway. The human

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