SAB4200239
Anti-Alpha4 antibody, Mouse monoclonal
clone 5F6, purified from hybridoma cell culture
别名:
Anti-IGBP1, Anti-Immunoglobulin-binding protein 1
biological source
mouse
conjugate
unconjugated
antibody form
purified from hybridoma cell culture
antibody product type
primary antibodies
clone
5F6, monoclonal
form
buffered aqueous solution
mol wt
antigen ~40 kDa
species reactivity
human, mouse
concentration
~1 mg/mL
technique(s)
western blot: 1-2 μg/mL using whole extracts of mouse 3T3 or human HeLa cells
isotype
IgG1
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... IGBP1(3476)
mouse ... Igbp1(18518)
General description
α 4 is a phosphoprotein that is expressed in a wide range of tissues, including pancreas, lymph node, thymus, kidney, leukocytes, fetal liver, heart, and brain. This phosporpotein associates with protein phosphatases 2A, 4, and 6 to regulate the rapamycin-sensitive pathway mediated by FRAP. α4 also binds to MID-1 and subsequently modulates PP2A function . Monoclonal Anti-α4 antibody is specific for human and mouse α4 (approx. 40 kDa).
Immunogen
mouse Alpha4 fusion protein. The corresponding sequence shares 80% homology with human Alpha4.
Application
Monoclonal Anti-α4 antibody is suitable for use in western blot (1-2 μg/mL using whole extracts of mouse 3T3 or human HeLa cells).
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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存储类别
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
J Chen et al.
Biochemical and biophysical research communications, 247(3), 827-832 (1998-07-02)
Protein phosphatases participate in the regulation of a variety of cellular processes. Control of their enzymatic activity and specificity is made possible largely by an array of regulatory subunits. Novel serine/threonine phosphatases--PP4 and PP6 in human cells--have been discovered recently
Haijuan Du et al.
PloS one, 6(12), e28877-e28877 (2011-12-24)
Alpha4 is a regulatory subunit of the protein phosphatase family of enzymes and plays an essential role in regulating the catalytic subunit of PP2A (PP2Ac) within the rapamycin-sensitive signaling pathway. Alpha4 also interacts with MID1, a microtubule-associated ubiquitin E3 ligase
Marketa Koncicka et al.
PloS one, 15(4), e0229781-e0229781 (2020-04-29)
Lamin C2 (LMN C2) is a short product of the lamin a gene. It is a germ cell-specific lamin and has been extensively studied in male germ cells. In this study, we focussed on the expression and localization of LMN
M Onda et al.
Genomics, 46(3), 373-378 (1998-01-27)
To study the function of the B cell signal transduction molecule alpha 4 (IGBP1), we isolated a human alpha 4 (IGBP1) gene that has sequence similarity to the yeast protein (TAP42) involved in the rapamycin-sensitive signal transduction pathway. The human
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