SAB4200254
Anti-SIRT6 antibody, Mouse monoclonal
clone SIRT6-4, purified from hybridoma cell culture
别名:
Monoclonal Anti-NAD-dependent deacetylase sirtuin-6, Monoclonal Anti-SIR2-like protein 6, Monoclonal Anti-SIR2L6, Monoclonal Anti-sirtuin 6
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关于此项目
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
SIRT6-4, monoclonal
Application:
IF, WB
Citations:
4
biological source
mouse
conjugate
unconjugated
antibody form
purified from hybridoma cell culture
antibody product type
primary antibodies
clone
SIRT6-4, monoclonal
form
buffered aqueous solution
mol wt
antigen ~40 kDa
species reactivity
human
concentration
~1.0 mg/mL
technique(s)
indirect immunofluorescence: suitable, western blot: 1-2 μg/mL using whole extracts of HEK-293T cells overexpressing human SIRT6.
isotype
IgG2b
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... SIRT6(51548)
mouse ... Sirt6(50721)
General description
Monoclonal Anti-SIRT6 (mouse IgG2b isotype) is derived from the hybridoma SIRT6-4 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with a synthetic peptide corresponding to the N-terminal region of human Sirt6 conjugated to KLH. Sirtuin 6 (Sirt6) belongs to the mammalian Sir2 gene family. It is a nuclear, chromatin-associated protein. Sirt6 is broadly expressed with the highest levels in muscle, brain and heart.
Immunogen
synthetic peptide corresponding to the N-terminal region of human Sirt6 (GeneID: 51548), conjugated to KLH.
Application
Monoclonal Anti-SIRT6 antibody produced in mouse has been used in immunoblotting.
Biochem/physiol Actions
Sirtuin 6 (Sirt6) plays a key role in DNA repair and maintenance of genomic stability in cells. Sirt6 is enzymatically inactive as a Nicotinamide adenine dinucleotide (NAD+) -dependent protein deacetylase but displays auto-adenosine triphosphate (ADP)-ribosyl transferase activity. Loss of Sirt6 leads to the development of an acute degenerative aging-like phenotype.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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存储类别
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
Mouse Sir2 homolog SIRT6 is a nuclear ADP-ribosyltransferase
Liszt G, et al.
The Journal of biological chemistry, 280(22), 21313-21320 (2005)
SIRT6 is a positive regulator of aldose reductase expression in U937 and HeLa cells under osmotic stress: in vitro and in silico insights
Timucin AC and Basaga H
PLoS ONE, 11(8), e0161494-e0161494 (2016)
Genomic instability and aging-like phenotype in the absence of mammalian SIRT6
Mostoslavsky R, et al.
Cell, 124(2), 315-329 (2006)
Ahmet Can Timucin et al.
PloS one, 11(8), e0161494-e0161494 (2016-08-19)
SIRT6 is a protein deacetylase, involved in various intracellular processes including suppression of glycolysis and DNA repair. Aldose Reductase (AR), first enzyme of polyol pathway, was proposed to be indirectly associated to these SIRT6 linked processes. Despite these associations, presence
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