SAB4200254
Anti-SIRT6 antibody, Mouse monoclonal
clone SIRT6-4, purified from hybridoma cell culture
别名:
Monoclonal Anti-NAD-dependent deacetylase sirtuin-6, Monoclonal Anti-SIR2-like protein 6, Monoclonal Anti-SIR2L6, Monoclonal Anti-sirtuin 6
生物来源
mouse
偶联物
unconjugated
抗体形式
purified from hybridoma cell culture
抗体产品类型
primary antibodies
克隆
SIRT6-4, monoclonal
表单
buffered aqueous solution
分子量
antigen ~40 kDa
种属反应性
human
浓度
~1.0 mg/mL
技术
indirect immunofluorescence: suitable
western blot: 1-2 μg/mL using whole extracts of HEK-293T cells overexpressing human SIRT6.
同位素/亚型
IgG2b
UniProt登记号
运输
dry ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... SIRT6(51548)
mouse ... Sirt6(50721)
一般描述
Monoclonal Anti-SIRT6 (mouse IgG2b isotype) is derived from the hybridoma SIRT6-4 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with a synthetic peptide corresponding to the N-terminal region of human Sirt6 conjugated to KLH. Sirtuin 6 (Sirt6) belongs to the mammalian Sir2 gene family. It is a nuclear, chromatin-associated protein. Sirt6 is broadly expressed with the highest levels in muscle, brain and heart.
免疫原
synthetic peptide corresponding to the N-terminal region of human Sirt6 (GeneID: 51548), conjugated to KLH.
应用
Monoclonal Anti-SIRT6 antibody produced in mouse has been used in immunoblotting.
生化/生理作用
Sirtuin 6 (Sirt6) plays a key role in DNA repair and maintenance of genomic stability in cells. Sirt6 is enzymatically inactive as a Nicotinamide adenine dinucleotide (NAD+) -dependent protein deacetylase but displays auto-adenosine triphosphate (ADP)-ribosyl transferase activity. Loss of Sirt6 leads to the development of an acute degenerative aging-like phenotype.
外形
0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
12 - Non Combustible Liquids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
此项目有
Genomic instability and aging-like phenotype in the absence of mammalian SIRT6
Mostoslavsky R, et al.
Cell, 124(2), 315-329 (2006)
SIRT6 is a positive regulator of aldose reductase expression in U937 and HeLa cells under osmotic stress: in vitro and in silico insights
Timucin AC and Basaga H
PLoS ONE, 11(8), e0161494-e0161494 (2016)
Ahmet Can Timucin et al.
PloS one, 11(8), e0161494-e0161494 (2016-08-19)
SIRT6 is a protein deacetylase, involved in various intracellular processes including suppression of glycolysis and DNA repair. Aldose Reductase (AR), first enzyme of polyol pathway, was proposed to be indirectly associated to these SIRT6 linked processes. Despite these associations, presence
Mouse Sir2 homolog SIRT6 is a nuclear ADP-ribosyltransferase
Liszt G, et al.
The Journal of biological chemistry, 280(22), 21313-21320 (2005)
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