Anti-YY1 antibody produced in rabbit

The Yin Yang-1 (YY1) gene encodes a ubiquitous, conserved, multifunctional zinc-finger transcription factor. It is a phosphoprotein and a member of the polycomb group protein family. The YY1 gene is mapped to human chromosome 14q32.2. Alternative splicing of the gene produces eight different transcripts. The YY1 protein possesses four C2H2-type zinc-finger motifs and two specific domains as an activator or a repressor.

synthetic peptide corresponding to an Internal region of human YY1, conjugated to KLH. The corresponding sequence is identical in rat.

Anti-YY1 antibody produced in rabbit is has been used in immunofluorescence. It is suitable for immunoblotting.

Anti-YY1 recognizes human YY1.

Yin Yang-1 gene (YY1) significantly participates in hematopoiesis and cell cycle control. The YY1 protein regulates initiation, activation, or repression of transcription of a variety of genes required for cell growth, development, differentiation, or tumor suppression, depending upon the context in which it binds. YY1 overexpression is associated with cellular proliferation, resistance to Fas ligand-mediated apoptosis, tumorigenesis and metastatic prostate cancer.

Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.

For continuous use, store at 2-8 °C for up to one month. For extended storage, freeze in working aliquots. Repeated freezing and thawing, or storage in “frost-free” freezers,is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilutions should be discarded if not used within 12 hours.

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