Anti-RAMP2 (N-terminal) antibody produced in rabbit

The receptor activity-modifying protein 2 (RAMP2) gene is mapped to human chromosome 17q21.2. RAMPs 1-3 are a novel class of single transmembrane accessory proteins. While mammalian RAMPs 1-3 significantly differ in sequence homology and tissue distribution, they possess comparable structure, with a long extracellular N-terminus, a single transmembrane domain, and a short cytoplasmic C-terminus.

synthetic peptide corresponding to a sequence located near the N-terminal of human RAMP2, conjugated to KLH

Anti-RAMP2 (N-terminal) antibody produced in rabbit is suitable for immunoblotting.

Anti-RAMP2 (N-terminal) specifically recognizes human RAMP2.

Receptor activity-modifying proteins (RAMPs 1-3) are essential for the function of various G-protein coupled receptors (GPCRs). Preferential adrenomedullin (AM) binding is established by the interaction between calcitonin receptor-like receptor (CLR or CRLR) and RAMP2. Tissue-specific analysis of the human and mouse transcriptomes shows that the formation of a functional AM receptors is possible with most CLR being complexed with RAMP2. RAMP2 is required for the transport of AM receptor and for presenting it at the cell surface as a mature glycoprotein. RAMP2 is essential for angiogenesis and vascular integrity, and for lymphatic vascular development during embryogenesis. RAMPs represent as potential targets for the treatment of human diseases related to either AM or calcitonin gene-related peptide (CGRP) physiology.

Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.

For continuous use, store at 2-8 °C for up to one month. For extended storage, freeze in working aliquots. Repeated freezing and thawing, or storage in “frost-free” freezers,is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilutions should be discarded if not used within 12 hours.

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.