Anti-Recoverin (C-terminal) antibody produced in rabbit

The recoverin (RCVRN) gene is mapped to human chromosome 17p13.1. Recoverin is a neuronal calcium (Ca²⁺) sensor (NCS) protein and contains four EF-hand Ca²⁺-binding sites. Recoverin is mainly localized in the retina, in cone and rod photoreceptors, cone bipolar cells, and in a subpopulation of cells in the ganglion cell layer.

synthetic peptide corresponding to a sequence at the C-terminus of rat recoverin, conjugated to KLH. The corresponding sequence is identical in mouse recoverin and highly conserved (86% sequence identity) in human recoverin.

Anti-Recoverin (C-terminal) antibody produced in rabbit is suitable for immunoblotting.

Anti-Recoverin (C-terminal) specifically recognizes human and rat recoverin.

Recoverin plays an important role in phototransduction. The neuronal calcium (Ca²⁺) sensor (NCS) proteins are involved in a variety of Ca²⁺-dependent signal transduction processes in neurons. Recoverin is expressed in early stages of development, thus providing an effective marker to assess the development of photoreceptors in the retina. Recoverin serves as a Ca²⁺ -dependent regulator of rhodopsin kinase (GRK1)/rhodopsin kinase that catalyzes the phosphorylation and desensitization of visual receptor rhodopsin. Recoverin has been suggested to interact with additional NCS proteins, including caldendrin, to modulate its activity. Recoverin has also been identified as an autoantigen in the degenerative disease of the retina cancer-associated neuropathy (CAR). The aberrant expression of recoverin in malignant tumors has been shown to cause an autoimmune response in some cancer patients that leads to the development of paraneoplastic CAR syndrome.

Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.

For continuous use, store at 2-8 °C for up to one month. For extended storage, freeze in working aliquots. Repeated freezing and thawing, or storage in “frost-free” freezers,is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilutions should be discarded if not used within 12 hours.

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