Anti-PRKACA antibody produced in rabbit

PRKACA is a serine threonine kinase that phosphorylates various proteins to facilitate several cellular functions. For instance, PRAKACA phosphorylates TRPC1 channel to modulate Ca²⁺ entry in endothelial tissues and regulates DNA binding functions by phosphorylation of NF-κB p50. PRAKACA also mediates tight junction barrier activity by phosphorylation of claudin-3. Additionally, PRAKACA has been associated with body mass index of asthma patients and the pathogenesis of diabetic osteoporosis
Anti-PRKACA antibody is specific for human PRKACA. In immunoblotting, staining of the PRKACA band is specifically inhibited by the immunizing peptide.

synthetic peptide corresponding to the N-terminal region of human PRKACA, conjugated to KLH. The corresponding sequence differs by 2 and 3 amino acids in mouse and rat, respectively

Anti-PRKACA antibody is suitable for use in western blot (0.25-0.5 μg/mL) using lysates of HEK-293T cells over-expressing human PRKACA.

Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.

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