biological source
rabbit
conjugate
unconjugated
antibody form
IgG fraction of antiserum
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen ~139 kDa, antigen ~150 kDa, antigen ~210 kDa
species reactivity
human
technique(s)
western blot: 1:250-1:500 using lysates of HEK-293T cells over-expressing human PTPRF.
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... PTPRF(5792)
General description
PTPRF removes phosphate group from β-catenin, an event that may subsequently facilitate cell-cell adhesion and ensure the stability of the cadherin complex. This phosphatase has also been implicated in various cellular processes such as neurite growth, nerve regeneration, actin remodeling and regulation of insulin function .
Immunogen
synthetic peptide corresponding to an internal region of human PTPRF, conjugated to KLH. The corresponding sequence differs by two amino acids in mouse and rat.
Application
Anti-PTPRF antibody is suitable for use in immunoblot (1:250-1:500 using lysates of HEK-293T cells over-expressing human PTPRF).
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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存储类别
12 - Non Combustible Liquids
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
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相关内容
Instructions
Mélanie J Chagnon et al.
Biochemistry and cell biology = Biochimie et biologie cellulaire, 82(6), 664-675 (2005-01-28)
The protein tyrosine phosphatases (PTPs) have emerged as critical players in diverse cellular functions. The focus of this review is the leukocyte common antigen-related (LAR) subfamily of receptor PTPs (RPTPs). This subfamily is composed of three vertebrate homologs, LAR, RPTP-sigma
Robert A Mooney et al.
Current topics in medicinal chemistry, 3(7), 809-819 (2003-04-08)
The leukocyte common antigen-related protein, LAR, is a receptor-like protein tyrosine phosphatase (PTP) which has a wide tissue distribution. Post-translational processing cleaves the proprotein into two non-covalently associated subunits, an extracellular subunit resembling a cell adhesion molecule with three immunoglobulin-like
M Streuli et al.
The EMBO journal, 11(3), 897-907 (1992-03-01)
The human transmembrane molecule LAR is a protein tyrosine phosphatase (PTPase) with a cell adhesion molecule-like extracellular receptor region. The structure of LAR hinted at its involvement in the regulation of tyrosine phosphorylation through cell-cell or cell-matrix interactions. We show