SAB4200326
Anti-LRP1B (C-terminal region) antibody produced in rabbit
~1.5 mg/mL, affinity isolated antibody
别名:
Anti-LRP-DIT, Anti-LRPDIT, Anti-Low density lipoprotein receptor-related protein 1B
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关于此项目
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
IF, IP, WB
Citations:
5
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen ~190 kDa (Rat), antigen ~200 kDa (Human)
species reactivity
human, rat, mouse
concentration
~1.5 mg/mL
technique(s)
immunoprecipitation (IP): 5-10 μg using extracts of HEK-293T cells overexpressing human LRP1B., indirect immunofluorescence: 1-2 μg/mL using HEK-293T cells overexpressing human LRP1B., western blot: 1.5-3.0 μg/mL using extracts of rat brain (S1 fraction) and mouse brain (S1 fraction).
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... LRP1B(53353)
mouse ... Lrp1b(94217)
rat ... Lrp1b(311926)
General description
LDL receptor-related protein 1B (LRP1B) belongs to the low-density lipoprotein (LDL) receptor gene family, including LDLR, LRPs (low density lipoprotein related proteins), megalin/GP330, VLDLR (very low density lipoprotein receptor) and ApoER2.
Immunogen
synthetic peptide corresponding to a sequence near the C-terminus of human LRP1B, conjugated to KLH. The corresponding sequence is identical in mouse LRP1B.
Application
Anti-LRP1B (C-terminal region) antibody produced in rabbit has been used in:
- immunoblotting
- immunoprecipitation
- immunofluorescence
Biochem/physiol Actions
LDL receptor-related protein 1B (LRP1B) is a candidate tumor suppressor gene, that is inactivated in several types of human malignancies, including non-small cell lung cancer (NSCLC) and plays an important role in tumorigenesis. It regulates the endocytic trafficking of the β-amyloid precursor protein (APP) and reduces the production of amyloid-β peptide (Ab) involved in the pathogenesis of Alzheimer′s disease. LRP1B regulates the degradation of the platelet derived growth factor-β receptor (PDGFR-β) and is implicated in the development of atherosclerosis.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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存储类别
10 - Combustible liquids
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
低风险生物材料
常规特殊物品
此项目有
Joana Peixoto et al.
International journal of molecular sciences, 24(14) (2023-07-29)
LRP1B remains one of the most altered genes in cancer, although its relevance in cancer biology is still unclear. Recent advances in gene editing techniques, particularly CRISPR/Cas9 systems, offer new opportunities to evaluate the function of large genes, such as
gamma-Secretase-mediated release of the low density lipoprotein receptor-related protein 1B intracellular domain suppresses anchorage-independent growth of neuroglioma cells
Liu CX, et al.
The Journal of Biological Chemistry, 282(10), 7504-7511 (2007)
The low density lipoprotein receptor-related protein 1B retains beta-amyloid precursor protein at the cell surface and reduces amyloid-beta peptide production
Cam JA, et al.
The Journal of Biological Chemistry, 279(28), 29639-29646 (2004)
Can-Hui Cao et al.
International journal of biological sciences, 17(7), 1744-1756 (2021-05-18)
Human papillomavirus (HPV) infection and gene mutations were reputed as key factors in cervical carcinoma (CC) and head and neck squamous cell carcinoma (HNSCC). However, the associations of HPV status and gene mutations remain to be determined. This study aims
Apolipoprotein E and its receptors in Alzheimer's disease: pathways, pathogenesis and therapy
Bu G
Nature Reviews. Neuroscience, 10(5), 333-333 (2009)
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