Anti-GUSB (C-terminal) antibody produced in rabbit

Glucuronidase β (GUSB), an exoglycosidase, is a member of the glycosyl hydrolase 2 family. The GUSB protein has a homotetrameric structure that is found in the lysosome. It contains three structural domains, such as a jelly roll barrel, an immunoglobulin constant domain and a triosephosphate isomerase (TIM) barrel respectively. The gene GUSB is mapped to the human chromosome location 7q11.21.

a synthetic peptide corresponding to a sequence at the C-terminal region of human GUSB, conjugated to KLH. The corresponding sequence is identical in mouse and differs by a single amino acid in rat.

Anti-GUSB (C-terminal) antibody produced in rabbit may be used in immunoblotting and immunohistochemistry.

Anti-GUSB (C-terminal) recognizes human and rat GUSB.

Glucuronidase β (GUSB) is a hydrolase that degrades glycosaminoglycans (GAGs), such as heparan sulfate, dermatan sulfate and chondroitin-4,6-sulfate. In the absence of GUS, only partial degradation of GAGs takes place. This leads to the accumulation of GAGs in the lysosomes of many tissues, leading to cellular and organ dysfunction. Mutations in this gene lead to mucopolysaccharidosis type VII (Sly syndrome). Several pseudogenes of this locus are present in the human genome.

Solution in 0.01 M phosphate buffered saline pH 7.4, containing 15 mM sodium azide.

For continuous use, store at 2-8°C for up to one month. For extended storage freeze in working aliquots. Repeated freezing and thawing is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilution samples should be discarded if not used within 12 hours.

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