Anti-MLL2 antibody, Mouse monoclonal

Myeloid/lymphoid or mixed-lineage leukemia 2 (MLL2) belongs to the SET family of proteins. The SET domain of MLL2 confers strong histone 3 lysine 4 methyltransferase activity. MLL2 is part of a large protein complex called activating signal cointegrator-2 complex (ASCOM).

Fusion protein corresponding to the C-terminus of human MLL2. The corresponding sequence is identical in mouse and rat MLL2 and shares 85% homology with MLL3.

Monoclonal Anti-MLL2 antibody produced in mouse has been used in immunoblotting and immunofluorescence.

MLL2 acts as an epigenetic transcriptional activator during growth and development. It functions as a transcriptional regulator of the beta-globin and estrogen receptor genes. Mutations in this gene are linked to Kabuki syndrome.

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

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