SAB4200344
Anti-SMYD3 antibody, Mouse monoclonal
clone SMYD3-2, purified from hybridoma cell culture
别名:
Anti-KMT3E, Anti-SET and MYND domain containing 3, Anti-ZMYND1, Anti-Zinc finger MYND domain-containing protein 1, Anti-Zinc finger protein, subfamily 3A (MYND domain containing), 1
生物来源
mouse
偶联物
unconjugated
抗体形式
purified from hybridoma cell culture
抗体产品类型
primary antibodies
克隆
SMYD3-2, monoclonal
表单
buffered aqueous solution
分子量
antigen ~43 kDa
种属反应性
rat, mouse, human
浓度
~1.0 mg/mL
技术
western blot: 5-10 μg/mL using whole extracts of HeLa cells
同位素/亚型
IgG1
UniProt登记号
运输
dry ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... SMYD3(64754)
mouse ... Smyd3(69726)
rat ... Smyd3(498295)
一般描述
Monoclonal Anti-SMYD3 (mouse IgG1 isotype) is derived from the hybridoma SMYD3-2 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with a fusion protein corresponding to a fragment of human SMYD3. SMYD3 belongs to the SMYD family of chromatin regulators. It is a histone methyltransferase, that plays a role in transcriptional regulation as a member of an RNA polymerase complex. SMYD3 contains a SET domain, which is critical for the methylation of histone H3 at Lys4 and a myeloid, Nervy, and DEAF-1 (MYND)-type zinc-finger domain, which is common to developmental proteins.
免疫原
Fusion protein corresponding to a fragment of human SMYD3.
应用
Monoclonal Anti-SMYD3 antibody produced in mouse has been used in immunoblotting and immunoprecipitation.
生化/生理作用
SMYD3 is important in heart and skeletal muscle development. Overexpression of SMYD3 is observed in hepatocellular cancer, colorectal cancer and breast cancer. SMYD3 is essential for estrogen receptor-regulated gene transcription in the estrogen signaling pathway.
外形
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide as a preservative.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
10 - Combustible liquids
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
此项目有
Requirement of histone methyltransferase SMYD3 for estrogen receptor-mediated transcription
Kim H, et al.
The Journal of Biological Chemistry, 284(30), 19867-19877 (2009)
Structural insights into the autoinhibition and posttranslational activation of histone methyltransferase SmyD3
Sirinupong N, et al.
Journal of Molecular Biology, 406(1), 149-159 (2011)
SMYD3 encodes a histone methyltransferase involved in the proliferation of cancer cells
Hamamoto R, et al.
Nature Cell Biology, 6(8), 731-731 (2004)
Ewud Agborbesong et al.
Biomedicines, 12(3) (2024-03-28)
Autosomal dominant polycystic kidney disease (ADPKD) is the most common inherited kidney disorder worldwide and progresses to end-stage renal disease (ESRD). However, its precise mechanism is not fully understood. In recent years, epigenetic reprogramming has drawn increasing attention regarding its
Ewud Agborbesong et al.
International journal of molecular sciences, 25(11) (2024-06-19)
The primary cilium is a microtubule-based sensory organelle that plays a critical role in signaling pathways and cell cycle progression. Defects in the structure and/or function of the primary cilium result in developmental diseases collectively known as ciliopathies. However, the
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