SAB4200370
Anti-PVRL4 antibody, Mouse monoclonal
clone N4.101.10, purified from hybridoma cell culture
别名:
Monoclonal Anti-Nectin-4/PVRL4 antibody produced in mouse, Monoclonal Anti-PVRL4 antibody produced in mouse, Anti-EDSS1, Anti-LNIR, Anti-Nectin-4, Anti-PRR4, Anti-PVRL4, Anti-Poliovirus receptor-related 4
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关于此项目
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
N4.101.10, monoclonal
Application:
FACS, ICC
Citations:
3
biological source
mouse
conjugate
unconjugated
antibody form
purified from hybridoma cell culture
antibody product type
primary antibodies
clone
N4.101.10, monoclonal
form
buffered aqueous solution
species reactivity
human
concentration
~1.0 mg/mL
technique(s)
flow cytometry: 5-10 μg/test using using 1x106 MDA-MB-231 cells, immunocytochemistry: 2.5-5 μg/mL using using MDA-MB-231 cells
isotype
IgG1
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... PVRL4(81607)
General description
Monoclonal Anti-Nectin-4/PVRL4 (mouse IgG1 isotype) is derived from the hybridoma R2.525.2 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with human nectin4-Fc recombinant protein. Nectin-4 belongs to the family of Nectins. It forms homo-cis-dimers and then homo- or hetero-trans-dimers through the extracellular region in a Ca2+-independent manner. Nectin-4 is expressed in placenta, ductal breast carcinoma and lung adenocarcinomas. It is one of the plasma membrane components of adherens junctions.
Immunogen
human Nectin4/Fc recombinant protein
Application
Monoclonal Anti-PVRL4 antibody produced in mouse has been used in immunocytochemistry and flow cytometry.
Biochem/physiol Actions
Nectin-4 is involved in cell adhesion through trans homophilic and heterophilic interactions. Mutations in this gene are associated with ectodermal dysplasia-syndactyly syndrome type 1.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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存储类别
10 - Combustible liquids
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
低风险生物材料
常规特殊物品
此项目有
Nectin-4 is a new histological and serological tumor associated marker for breast cancer
Fabre-Lafay S, et al.
BMC Cancer, 7(1), 73-73 (2007)
Stephanie Fabre et al.
The Journal of biological chemistry, 277(30), 27006-27013 (2002-05-16)
Nectins form a family of integral molecules that belong to the immunoglobulin superfamily. Their ectodomain is made of three Ig-like domains (V, C, C). This family comprises at least five members, namely nectin1, -2, -3, -4, and poliovirus receptor (PVR)
Francesco Brancati et al.
American journal of human genetics, 87(2), 265-273 (2010-08-10)
Ectodermal dysplasias form a large disease family with more than 200 members. The combination of hair and tooth abnormalities, alopecia, and cutaneous syndactyly is characteristic of ectodermal dysplasia-syndactyly syndrome (EDSS). We used a homozygosity mapping approach to map the EDSS
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