SAB4200376
Anti-Atg13 antibody, Mouse monoclonal
clone ATG13-8, purified from hybridoma cell culture
别名:
Monoclonal Anti-Atg13 antibody produced in mouse, Monoclonal Anti-Autophagy related 13 homolog (S. cerevisiae), Monoclonal Anti-KIAA0652
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关于此项目
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
ATG13-8, monoclonal
Application:
IP, WB
Citations:
2
biological source
mouse
conjugate
unconjugated
antibody form
purified from hybridoma cell culture
antibody product type
primary antibodies
clone
ATG13-8, monoclonal
form
buffered aqueous solution
mol wt
antigen ~65 kDa
species reactivity
human, mouse, rat
concentration
~1.0 mg/mL
technique(s)
immunoprecipitation (IP): 5-10 μg using lysates of mouse LA-4 cells., western blot: 1-2 μg/mL using whole extracts of HEK-293T cells over expressing human Atg13.
isotype
IgG2a
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... ATG13(9776)
mouse ... Atg13(51897)
rat ... Atg13(362164)
General description
Monoclonal Anti-ATG13 (mouse IgG2a isotype) is derived from the hybridoma ATG13-8 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice.
Immunogen
synthetic peptide corresponding to the C-terminal region of human ATG13, conjugated to KLH. The corresponding sequence is identical in mouse and rat Atg13.
Application
Monoclonal Anti-Atg13 antibody produced in mouse has been used in immunoblotting and immunoprecipitation.
Biochem/physiol Actions
Atg13 is essential for autophagosome formation in mammalian cells. Atg13 forms a stable complex with UNC-51-like kinase 1 (ULK1) and family-interacting protein of 200 kDa (FIP200).
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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存储类别
10 - Combustible liquids
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
低风险生物材料
常规特殊物品
此项目有
Nutrient-dependent mTORC1 association with the ULK1-Atg13-FIP200 complex required for autophagy
Hosokawa N, et al.
Molecular Biology of the Cell, 20(7), 1981-1991 (2009)
Tomokazu Murakawa et al.
Cell reports, 26(2), 338-345 (2019-01-10)
Degradation of mitochondria by selective autophagy, termed mitophagy, contributes to the control of mitochondrial quality. Bcl2-L-13 is a mammalian homolog of Atg32, which is an essential mitophagy receptor in yeast. However, the molecular machinery involved in Bcl2-L-13-mediated mitophagy remains to
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