SAB4200379
Anti-JMY antibody produced in rabbit
~1.0 mg/mL, affinity isolated antibody
别名:
Anti-Junction mediating and regulatory protein, Anti-p53 cofactor
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关于此项目
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
IF, IP, WB
Citations:
3
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen ~120 kDa
species reactivity
human
concentration
~1.0 mg/mL
technique(s)
immunoprecipitation (IP): 5-10 μg using lysates of human WiDr cells., indirect immunofluorescence: 1-2 μg/mL using human HeLa cells., western blot: 0.5-1.0 μg/mL using whole extracts of human WiDr cells
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... JMY(133746)
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General description
Junction mediating and regulatory protein (JMY) is identified as a transcriptional co-activator of p53 and is a multifunctional actin nucleation factor. JMY contains Wiskott-Aldrich syndrome protein (WASp)-homology 2 (WH2) domains in its C-terminus. The JMY gene is mapped to human chromosome location 5q14.1.
Immunogen
synthetic peptide corresponding to the C-terminal region of human JMY, conjugated to KLH.
Application
Anti-JMY antibody produced in rabbit may be used in:
- immunoblotting
- immunoprecipitation
- immunofluorescence.
Biochem/physiol Actions
Anti-JMY recognizes human JMY.
Junction mediating and regulatory protein (JMY) acts as a nucleation promoting factor by activating actin-related proteins-2/3 (ARP2/3), creating branched filament networks, and also by assembling unbranched filaments directly through a Spire-like mechanism. Overexpression of JMY increases motility while its loss slows cell migration. DNA damage causes JMY to accumulate in the nucleus, where it enhances p53-dependent transcription of pro-apoptotic genes. The activities of JMY as a p53 co-factor or as an actin nucleation factor are regulated by its subcellular localization.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
Preparation Note
For continuous use, store at 2-8 °C for up to one month. For extended storage, freeze in working aliquots. Repeated freezing and thawing, or storage in “frost-free” freezers, is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilutions should be discarded if not used within 12 hours.
Disclaimer
Unless otherwise stated in our catalog, our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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存储类别
10 - Combustible liquids
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
p53-cofactor JMY is a multifunctional actin nucleation factor
Zuchero JB, et al.
Nature Cell Biology, 11(4), 451-459 (2009)
A transcription co-factor integrates cell adhesion and motility with the p53 response
Coutts AS, et al.
Proceedings of the National Academy of Sciences, 106(47), 19872-19877 (2009)
Identification of differentially expressed genes in uveal melanoma using suppressive subtractive hybridization
Landreville S, et al.
Molecular Vision, 17, 1324-1324 (2011)
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