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Merck
CN

SAB4200403

Anti-EXOSC8 (N-terminal) antibody produced in rabbit

~1.0 mg/mL, affinity isolated antibody

别名:

Anit-CIP3, Anit-Exosome component 8,p9, Anti-EAP2, Anti-OIP2, Anti-Opa interacting protein 2, Anti-RP11-421P11.3, Anti-RRP43, Anti-Ribosomal RNA-processing protein 43, Anti-Rrp43p, AntiCBP-interacting protein 3

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关于此项目

NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
IP, WB
Citations:
2

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biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen ~34 kDa

species reactivity

mouse, human, rat

concentration

~1.0 mg/mL

technique(s)

immunoprecipitation (IP): 1-2 μg using human HEK-293T cell lysate, western blot: 1-2 μg/mL using whole extracts of mouse A20 and rat PC12 cells

UniProt accession no.

Q96B26

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Quality Level

200

Gene Information

bovine ... EXOSC8(532080)
dog ... EXOSC8(477300)
human ... EXOSC8(11340)
mouse ... Exosc8(69639)

General description

Exosome component 8 (EXOSC8) or RRP43, a 3′ to 5′ exoribonuclease, is a component of the eukaryotic exosome (a 400 kDa complex). EXOSC8 is part of the hexameric ring, along with EXOSC4-7 and EXOSC9. This is further capped by three RNA binding subunits (EXOSC1-EXOSC3). EXOSC8 gene is mapped to human chromosome 13q13.3 and is localized in nucleus and cytoplasm.

Immunogen

peptide corresponding to the N-terminal region of human EXOSC8, conjugated to KLH.

Application

Anti-EXOSC8 (N-terminal) antibody produced in rabbit may be used in immunoblotting and immunoprecipitation.

Biochem/physiol Actions

Anti-EXOSC8 (N-terminal) recognizes human, mouse and rat EXOSC8.
Exosome component 8 (EXOSC8) interacts with AU-rich element (ARE)-containing mRNAs and its deficiency halts growth in yeast. Mutations in the EXOSC8 gene is implicated in Ponto-cerebellar hypoplasia.

Physical form

Solution in 0.01 M phosphate buffered saline pH 7.4, containing 15 mM sodium azide.

Preparation Note

For continuous use, store at 2-8°C for up to one month. For extended storage freeze in working aliquots. Repeated freezing and thawing is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilution samples should be discarded if not used within 12 hours.

Disclaimer

Unless otherwise stated in our catalog, our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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存储类别

10 - Combustible liquids

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

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分析证书(COA)

Lot/Batch Number
121M4770

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Pontocerebellar hypoplasia with rhombencephalosynapsis and microlissencephaly expands the spectrum of PCH type 1B
Saugier-Veber P, et al.
European Journal of Medical Genetics, 63(4), 103814-103814 (2020)
Identification of the phytosphingosine metabolic pathway leading to odd-numbered fatty acids
Kondo N, et al.
Nature Communications, 5(1), 1-13 (2014)

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