SAB4200410
Anti-Rheb (C-terminal region) antibody produced in rabbit
~1.0 mg/mL, affinity isolated antibody
别名:
Anti-RHEB2, Anti-Ras homolog enriched in brain
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关于此项目
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
IF, WB
Citations:
3
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen ~20 kDa
species reactivity
human, rat
enhanced validation
recombinant expression
Learn more about Antibody Enhanced Validation
concentration
~1.0 mg/mL
technique(s)
indirect immunofluorescence: 5-10 μg/mL using HEK-293T cells overexpressing human Rheb., western blot: 0.5-1 μg/mL using cell lysates of HEK-293T overexpressing human Rheb.
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... RHEB(6009)
rat ... Rheb(26954)
General description
Ras homolog enriched in brain (Rheb), a member of the family of Ras small G-proteins, is a cellular immediate early gene in the brain. It has a C-terminal CaaX box.
Immunogen
synthetic peptide corresponding to a sequence at the C-terminal region of human Rheb, conjugated to KLH. The corresponding sequence is identical in rat Rheb and highly conserved (94% sequence identity) in mouse Rheb.
Application
Anti-Rheb (C-terminal region) antibody produced in rabbit has been used in immunoblotting and immunofluorescence.
Biochem/physiol Actions
Ras homolog enriched in brain (Rheb) plays an important role in cell growth, proliferation, apoptosis, autophagy and neuronal axonal regeneration. The effects of Rheb are mediated via the mammalian target of rapamycin (mTOR) protein kinase. Rheb activity in mTor signaling is regulated by a dual mechanism. Rheb appears to activate mTOR complex 1 (mTORC1) via direct binding to mTOR. Rheb is required for mTORC1 signaling and myelination during brain development.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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存储类别
10 - Combustible liquids
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Rheb binds and regulates the mTOR kinase
Long X, et al.
Current Biology, 15(8), 702-713 (2005)
Rheb1 is required for mTORC1 and myelination in postnatal brain development
Zou J, et al.
Developmental Cell, 20(1), 97-108 (2011)
Localization of Rheb to the endomembrane is critical for its signaling function
Buerger C, et al.
Biochemical and biophysical research communications, 344(3), 869-880 (2006)
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