Anti-non-phospho-TDP-43 antibody produced in rabbit

TAR DNA binding protein, TARDP (TDP-43) belongs to the family of heterogeneous nuclear ribonucleoproteins (hnRNPs) that bind single stranded RNA. TDP-43 is predominantly localized to the nucleus. This gene is mapped to human chromosome 1p36.22.

synthetic peptide containing non-phosphorylated Ser⁴⁰⁹ and Ser⁴¹⁰ of human TDP-43, conjugated to KLH. The corresponding sequence is identical in mouse TDP-43.

Anti-non-phospho-TDP-43 antibody produced in rabbit has been used in immunoblotting and immunofluorescence.

Anti-non-phospho-TDP-43 specifically recognizes human and mouse TDP-43 non-phosphorylated on Ser⁴⁰⁹ and Ser⁴¹. Detection of the non-phosphorylated TDP-43 band by immunoblotting is specifically inhibited by the non-phosphorylated TDP-43 immunizing peptide, but not by the corresponding mono-phosphorylated peptides TDP-43 [pSer⁴⁰⁹] and TDP-43 [pSer⁴¹⁰].

Members of the heterogeneous nuclear ribonucleoprotein (hnRNP) family play multiple roles in the generation and processing of RNA, including transcription, splicing, transport and stability. TAR DNA binding protein, TARDP (TDP-43) has been implicated in the transcription regulation of human immunodeficiency viruses (HIV). TDP-43 has been identified as the major ubiquinated component of cytoplasmic inclusions in frontotemporal lobe degeneration subtype frontotemporal lobar degeneration with ubiquitin-immunoreactive (ub-ir) inclusions (FTLD-U) and amyotrophic lateral sclerosis (ALS).

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

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