SAB4200417
Anti-XPO4 antibody, Mouse monoclonal
clone XP-12, purified from hybridoma cell culture
别名:
Anti-Exportin 4, Anti-KIAA1721, Monoclonal Anti-Exp4, Monoclonal Anti-XPO4 antibody produced in mouse
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关于此项目
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
XP-12, monoclonal
Application:
IF, WB
Citations:
5
biological source
mouse
conjugate
unconjugated
antibody form
purified from hybridoma cell culture
antibody product type
primary antibodies
clone
XP-12, monoclonal
form
buffered aqueous solution
mol wt
antigen ~130 kDa
species reactivity
bovine, chicken, hamster, monkey, canine, human
concentration
~1.0 mg/mL
technique(s)
indirect immunofluorescence: suitable, western blot: 1.0-2.0 μg/mL using extracts of HeLa cells
isotype
IgG1
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... XPO4(64328)
General description
Monoclonal Anti-XPO4 (mouse IgG1 isotype) is derived from the hybridoma XP-12 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with a peptide. Exportin 4 (XPO4) belongs to the karyopherins protein family. It is conserved amongst higher eukaryotes but, lacks obvious orthologues in yeast.
Immunogen
a peptide corresponding to a sequence at the C-terminus of human XPO4.
Application
Monoclonal Anti-XPO4 antibody produced in mouse has been used in immunoblotting and immunofluorescence.
Biochem/physiol Actions
Exportin 4 (XPO4) facilitates the nuclear export of eIF-5A (eukaryotic translation initiation factor 5A). In addition, it also mediates transport Sox proteins, as well as regulates Smad signaling. These functions of XPO4 suggests it to be a candidate tumor suppressor gene. Indeed, its involvement in the progression of human hepatocellular carcinomas (HCC) has been demonstrated, implicating this protein as a potential target for treatment of HCC.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
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存储类别
10 - Combustible liquids
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Exportin 4: a mediator of a novel nuclear export pathway in higher eukaryotes
Lipowsky G, et al.
The Embo Journal, 19, 4362-4371 (2000)
Decreased expression of XPO4 is associated with poor prognosis in hepatocellular carcinoma
Liang XT, et al.
Journal of Gastroenterology and Hepatology, 26, 544-549 (2011)
The Mechanism of Nuclear Export of Smad3 Involves Exportin 4 and Ran
Kurisaki A, et al.
Molecular and Cellular Biology, 26, 1318-1318 (2006)
Exportin 4 mediates a novel nuclear import pathway for Sox family transcription factors
Gontan C, et al.
The Journal of Cell Biology, 185, 27-27 (2009)
Megumi Tsuchiya et al.
PloS one, 6(10), e25694-e25694 (2011-10-13)
Sox9 is a transcription factor that is required for tissue development in mammals. In general, such transcription factors require co-regulators for precise temporal and spatial control of the activation and inactivation of the numerous genes necessary for precise development during
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