SAB4200427
Anti-COG8 (C-terminal) antibody produced in rabbit
~1.0 mg/mL, affinity isolated antibody
别名:
Anti-CDG2H, Anti-COG complex subunit 8, Anti-Component of oligomeric golgi complex 8, Anti-conserved oligomeric Golgi complex subunit 8, Anti-conserved oligomeric golgi complex component 8, Anti-dependent on RIC1, AntiDOR1
登录 查看组织和合同定价。
选择尺寸
关于此项目
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
IF, IP, WB
Citations:
6
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen ~70 kDa
species reactivity
human
concentration
~1.0 mg/mL
technique(s)
immunoprecipitation (IP): 5-10 μg using lysates of human HEK-293T cells, indirect immunofluorescence: 0.5-1.0 μg/mL using using human HeLa cells, western blot: 1-2 μg/mL using whole extracts of human HEK-293 cells
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... COG8(84342)
General description
Conserved oligomeric Golgi complex 8 (COG8), also known as DOR1 or CDG2H, is a member of the conserved oligomeric Golgi (COG) complex. COG complex is composed of eight distinct subunits organized as heterotrimeric groups namely Cog2-Cog3-Cog4 and Cog5-Cog6-Cog7. They are interlinked by the dimeric group comprising Cog1 and Cog8.
Immunogen
synthetic peptide corresponding to the C-terminal region of human COG8, conjugated to KLH
Application
Anti-COG8 (C-terminal) antibody produced in rabbit may be used in:
- immunoblotting
- immunoprecipitation
- immunofluorescence
Biochem/physiol Actions
Anti-COG8 (C-terminal) recognizes human COG8.
COG complex, is an evolutionarily conserved multi-subunit protein complex that regulates membrane trafficking and maintenance of Golgi glycosylation machinery in eukaryotic cells. Mutations in the COG8 gene cause congenital disorder of glycosylation, type IIh, a disease that is characterized by under-glycosylated serum proteins, and whose symptoms include severe psychomotor retardation, failure to thrive, seizures, and dairy and wheat product intolerance.
Physical form
Solution in 0.01 M phosphate buffered saline pH 7.4, containing 15 mM sodium azide
Preparation Note
For continuous use, store at 2-8 °C for up to one month. For extended storage freeze in working aliquots. Repeated freezing and thawing is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilution samples should be discarded if not used within 12 hours.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
未找到合适的产品？
试试我们的产品选型工具.
存储类别
10 - Combustible liquids
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
低风险生物材料
此项目有
Modeling congenital disorders of N-linked glycoprotein glycosylation in Drosophila melanogaster
Frappaolo A, et al.
Frontiers in Genetics, 9, 436-436 (2018)
COG8 deficiency causes new congenital disorder of glycosylation type IIh
Kranz C, et al.
Human Molecular Genetics, 16(7), 731-741 (2007)
Role of the conserved oligomeric Golgi (COG) complex in protein glycosylation
Smith RD and Lupashin VV
Carbohydrate Research, 343(12), 2024-2031 (2008)
Comparative analyses of the Conserved Oligomeric Golgi (COG) complex in vertebrates
Quental R, et al.
BMC Evolutionary Biology, 10(1), 212-212 (2010)
Amrita Khakurel et al.
Molecular biology of the cell, 32(17), 1594-1610 (2021-06-24)
The Golgi complex is a central hub for intracellular protein trafficking and glycosylation. Steady-state localization of glycosylation enzymes is achieved by a combination of mechanisms involving retention and recycling, but the machinery governing these mechanisms is poorly understood. Herein we
相关内容
Instructions
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持