Anti-BRSK2 antibody produced in rabbit

Brain selective kinase 2 (BRSK2) (SAD-A) protein belongs to the family of Ser/Thr 5′ adenosine monophosphate-activated protein kinase (AMPK) related kinases that are specifically expressed in the spinal cord and brain of embryonic and postnatal animals. The BRSK2 gene is located on the human chromosome at 11p15.5.

synthetic peptide corresponding to a sequence at an internal region of human BRSK2, conjugated to KLH. The corresponding sequence is identical in rat and mouse BRSK2.

Anti-BRSK2 antibody produced in rabbit may be used in immunoblotting.

Anti-BRSK2 specifically recognizes mouse BRSK2.

Brain selective kinase 2 (BRSK2) protein is phosphorylated by liver kinase B1 (LKB1) at Thr-174, increasing its kinase activity. This protein is also phosphorylated at Thr-260 by cyclic adenosine monophosphate (cAMP)-dependent protein kinase A (PKA) as another upstream kinase. Brain selective kinase 1/2 (BRSK1/2) in turn, phosphorylate downstream effectors such as the microtubule-associated protein tau and the cell cycle checkpoint kinase Wee1. Phosphorylation of Wee1 by BRSK1/2 is required for the regulation of its activity in polarized neurons and is an essential step for the differentiation of polarized neurons.

Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.

For continuous use, store at 2-8 °C for up to one month. For extended storage, freeze in working aliquots. Repeated freezing and thawing, or storage in “frost-free” freezers,is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Workingdilutions should be discarded if not used within 12 hours.

Unless otherwise stated in our catalog, our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.