SAB4200434
Anti-VHL antibody produced in rabbit
~1.0 mg/mL, affinity isolated antibody
别名:
Anti-HRCA1, Anti-RCA1, Anti-VHL1, Anti-Von Hippel-Lindau tumor supressor
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关于此项目
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
IF, IP, WB
Citations:
6
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen ~30 kDa
species reactivity
human
concentration
~1.0 mg/mL
technique(s)
immunoprecipitation (IP): 5-10 μg using lysates of HEK-293T cells overexpressing human VHL, indirect immunofluorescence: 5-10 μg/mL using HeLa cells, western blot: 1.5-3.0 μg/mL using lysates of HEK-293T cells overexpressing human VHL
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... VHL(7428)
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General description
Von Hippel-Lindau tumor suppressor (VHL) is encoded by the gene mapped to human chromosome 3p25. The encoded protein is mainly expressed in adult brain and kidney. It is specifically localized on the cell membrane.
Immunogen
synthetic peptide corresponding to a sequence near the C-terminus of human VHL, conjugated to KLH. The corresponding sequence is identical in human VHL isoform 2 and highly conserved (94% sequence identity) in rat VHL.
Application
Anti-VHL antibody produced in rabbit has been used in immunoblotting, immunoprecipitation and immunofluorescence.
Biochem/physiol Actions
VHL acts as part of an E3 ubiquitin ligase that targets hypoxia-inducible factor α (HIF α) for rapid proteasomal degradation under normoxic conditions. VHL has been also identified as a key regulator of microtubule dynamic stability.
Von Hippel-Lindau tumor suppressor (VHL) acts as a tumor suppressor in some cancers. It might also play a vital role in signal transduction or cell adhesion. Mutation in the gene is associated with the development of sporadic cerebellar hemangioblastoma tumorigenesis and von Hippel-Lindau (VHL) disease. Interaction of the protein with hypoxia-inducible factor-1 (HIF-1) induces mammalian oxygen sensing.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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存储类别
10 - Combustible liquids
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
The Clinicopathological Significance of Epigenetic Silencing of VHL Promoter and Renal Cell Carcinoma: A Meta-Analysis.
Yang L
Cellular Physiology and Biochemistry, 40, 1465-1472 (2016)
The VHL tumor suppressor and HIF: insights from genetic studies in mice
Kapitsinou PP and Haase VH
Cell Death and Differentiation, 15(4), 650-650 (2008)
Identification of the Von Hippel-Lindau Disease
Tumor Suppressor Gene
Latif F
Science, 260, 1317-1319 (2012)
Loss of Heterozygosity and Somatic Mutations of the VHL Tumor Suppressor Gene
in Sporadic Cerebellar Hemangioblastomas1
Lee JY
Cancer Research, 58, 504-508 (1998)
The tumour suppressor
protein VHL targets
hypoxia-inducible factors for
oxygen-dependent proteolysis
Maxwell PH
Nature, 399, 271-275 (1999)
相关内容
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